Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, USA.
Intramural Research Program, National Institute on Aging, Baltimore, MD, USA.
J Affect Disord. 2022 Nov 15;317:114-122. doi: 10.1016/j.jad.2022.07.067. Epub 2022 Aug 3.
We explored the associations of dual sensory impairment (DSI) with long-term depressive and anxiety symptoms as well as low perceived social support (LPSS) as a modifier of these associations.
Multinomial logistic regression models were used to examine the associations of DSI and single sensory impairment (hearing [pure-tone average > 25 dB] and vision [impaired visual acuity and/or contrast sensitivity]) with long-term depressive symptom (≥8 on the 10-item Center for Epidemiologic Studies-Depression Scale) and anxiety symptom (present on the Hopkins Symptom Checklist) latent classes from group-based trajectory models (rare/never; mild/moderate increasing; chronically high) among 2102 Health, Aging and Body Composition Study participants (mean age:74.0 ± 2.8 years; 51.9 % female) over 10 years. Models were adjusted by demographic characteristics and cardiovascular risk factors, and LPSS. An additional model evaluated the two-way interaction between DSI and LPSS.
DSI was associated with increased risk of being chronically depressed (Risk Ratio, RR = 1.99, 95 % Confidence Interval, CI: 1.25, 3.17), not mild/moderate increasingly depressed (RR = 1.25, 95 % CI: 0.91, 1.71). DSI had increased risk of being mild/moderate increasingly anxious (RR = 1.60, 95 % CI: 1.16, 2.19) and chronically anxious (RR = 1.86, 95 % CI: 1.05, 3.27) groups, as compared to no impairments. Hearing impairment was associated with being mild/moderate increasingly anxious (RR = 1.34, 95 % CI: 1.01, 1.79). No other associations were found for single sensory impairments. LPSS did not modify associations.
Sensory measures were time-fixed, and LPSS, depression and anxiety measures were self-reported.
Future research is warranted to determine if DSI therapies may lessen long-term chronically high depressive and anxiety symptoms.
我们探讨了双重感觉障碍(DSI)与长期抑郁和焦虑症状的关系,以及感知社会支持不足(LPSS)作为这些关系的调节剂的作用。
使用多项逻辑回归模型来研究 DSI 和单一感觉障碍(听力[纯音平均听力损失> 25dB]和视力[视力障碍和/或对比敏感度])与长期抑郁症状(10 项中心流行病学研究抑郁量表上≥8 分)和焦虑症状(霍普金斯症状清单上存在)的关联。研究纳入了 2102 名来自健康、衰老和身体成分研究的参与者(平均年龄:74.0±2.8 岁;51.9%为女性),在 10 年内采用基于群组轨迹模型(罕见/从不;轻度/中度增加;慢性高)进行分组。模型通过人口统计学特征和心血管危险因素以及 LPSS 进行了调整。还评估了 DSI 和 LPSS 之间的双向相互作用的额外模型。
DSI 与慢性抑郁(风险比 RR=1.99,95%置信区间 CI:1.25,3.17)的风险增加相关,与轻度/中度抑郁增加(RR=1.25,95% CI:0.91,1.71)无关。DSI 与轻度/中度焦虑增加(RR=1.60,95% CI:1.16,2.19)和慢性焦虑(RR=1.86,95% CI:1.05,3.27)组的风险增加相关,而无任何损伤。听力障碍与轻度/中度焦虑增加相关(RR=1.34,95% CI:1.01,1.79)。未发现单一感觉障碍与其他关联。LPSS 并未改变这些关联。
感觉测量是时间固定的,LPSS、抑郁和焦虑测量是自我报告的。
有必要开展进一步的研究,以确定 DSI 疗法是否可以减轻长期慢性高抑郁和焦虑症状。