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双重感觉障碍与美国长期抑郁和焦虑症状的关联。

Associations of dual sensory impairment with long-term depressive and anxiety symptoms in the United States.

机构信息

Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, USA.

Intramural Research Program, National Institute on Aging, Baltimore, MD, USA.

出版信息

J Affect Disord. 2022 Nov 15;317:114-122. doi: 10.1016/j.jad.2022.07.067. Epub 2022 Aug 3.

Abstract

OBJECTIVE

We explored the associations of dual sensory impairment (DSI) with long-term depressive and anxiety symptoms as well as low perceived social support (LPSS) as a modifier of these associations.

METHODS

Multinomial logistic regression models were used to examine the associations of DSI and single sensory impairment (hearing [pure-tone average > 25 dB] and vision [impaired visual acuity and/or contrast sensitivity]) with long-term depressive symptom (≥8 on the 10-item Center for Epidemiologic Studies-Depression Scale) and anxiety symptom (present on the Hopkins Symptom Checklist) latent classes from group-based trajectory models (rare/never; mild/moderate increasing; chronically high) among 2102 Health, Aging and Body Composition Study participants (mean age:74.0 ± 2.8 years; 51.9 % female) over 10 years. Models were adjusted by demographic characteristics and cardiovascular risk factors, and LPSS. An additional model evaluated the two-way interaction between DSI and LPSS.

RESULTS

DSI was associated with increased risk of being chronically depressed (Risk Ratio, RR = 1.99, 95 % Confidence Interval, CI: 1.25, 3.17), not mild/moderate increasingly depressed (RR = 1.25, 95 % CI: 0.91, 1.71). DSI had increased risk of being mild/moderate increasingly anxious (RR = 1.60, 95 % CI: 1.16, 2.19) and chronically anxious (RR = 1.86, 95 % CI: 1.05, 3.27) groups, as compared to no impairments. Hearing impairment was associated with being mild/moderate increasingly anxious (RR = 1.34, 95 % CI: 1.01, 1.79). No other associations were found for single sensory impairments. LPSS did not modify associations.

LIMITATIONS

Sensory measures were time-fixed, and LPSS, depression and anxiety measures were self-reported.

CONCLUSIONS

Future research is warranted to determine if DSI therapies may lessen long-term chronically high depressive and anxiety symptoms.

摘要

目的

我们探讨了双重感觉障碍(DSI)与长期抑郁和焦虑症状的关系,以及感知社会支持不足(LPSS)作为这些关系的调节剂的作用。

方法

使用多项逻辑回归模型来研究 DSI 和单一感觉障碍(听力[纯音平均听力损失> 25dB]和视力[视力障碍和/或对比敏感度])与长期抑郁症状(10 项中心流行病学研究抑郁量表上≥8 分)和焦虑症状(霍普金斯症状清单上存在)的关联。研究纳入了 2102 名来自健康、衰老和身体成分研究的参与者(平均年龄:74.0±2.8 岁;51.9%为女性),在 10 年内采用基于群组轨迹模型(罕见/从不;轻度/中度增加;慢性高)进行分组。模型通过人口统计学特征和心血管危险因素以及 LPSS 进行了调整。还评估了 DSI 和 LPSS 之间的双向相互作用的额外模型。

结果

DSI 与慢性抑郁(风险比 RR=1.99,95%置信区间 CI:1.25,3.17)的风险增加相关,与轻度/中度抑郁增加(RR=1.25,95% CI:0.91,1.71)无关。DSI 与轻度/中度焦虑增加(RR=1.60,95% CI:1.16,2.19)和慢性焦虑(RR=1.86,95% CI:1.05,3.27)组的风险增加相关,而无任何损伤。听力障碍与轻度/中度焦虑增加相关(RR=1.34,95% CI:1.01,1.79)。未发现单一感觉障碍与其他关联。LPSS 并未改变这些关联。

局限性

感觉测量是时间固定的,LPSS、抑郁和焦虑测量是自我报告的。

结论

有必要开展进一步的研究,以确定 DSI 疗法是否可以减轻长期慢性高抑郁和焦虑症状。

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