Cohen R A, Miller M E, Garcia J F, Moccia G, Cronkite E P
Exp Hematol. 1981 May;9(5):513-21.
The purpose of this study was twofold: (1) to define the relationship between erythropoietin (Ep) production and some of the coincident variables which control oxygen delivery in hypoxic and hypoxic-hypercarbic rats (2) to define the mechanism whereby hypercarbia suppresses Ep production in hypoxemic rats. Rats were exposed to O2 concentrations ranging from 5% to 9% O2 for either 3 or 16 h. Arterial whole blood pH, pCO2, pO2, O2 saturation, p50 and Ep levels were measured in each rat. There was a highly significant inverse correlation between both the arterial pO2 and O2 saturation and the Ep level. Ep levels were not increased above normal if the pO2 was greater than 50 mm Hg or the O2 saturation was greater than 80%. The addition of 5% CO2 to all inhaled gas mixtures was associated with a 10 mm Hg increment in the pO2 together with a marked reduction in plasma Ep levels. Of the measured variables only the pO2 and O2 saturation showed a consistent correlation with the Ep levels when rats exposed to hypoxia were compared with rats exposed to hypoxia + CO2.
（1）确定低氧和低氧 - 高碳酸血症大鼠中促红细胞生成素（Ep）产生与一些控制氧输送的相关变量之间的关系；（2）确定高碳酸血症抑制低氧血症大鼠中Ep产生的机制。将大鼠暴露于5%至9%的氧气浓度下3小时或16小时。测量每只大鼠的动脉全血pH、pCO₂、pO₂、氧饱和度、p50和Ep水平。动脉pO₂和氧饱和度与Ep水平之间均存在高度显著的负相关。如果pO₂大于50 mmHg或氧饱和度大于80%，Ep水平不会高于正常水平。向所有吸入气体混合物中添加5%的CO₂会使pO₂增加10 mmHg，同时血浆Ep水平显著降低。在比较暴露于低氧的大鼠和暴露于低氧 + CO₂的大鼠时，在所测量的变量中，只有pO₂和氧饱和度与Ep水平呈现出一致的相关性。
