Department of Orthopedics Oncology, Changzheng Hospital, Navy Medical University, Shanghai, 200003, China.
Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Adv Healthc Mater. 2022 Oct;11(20):e2201286. doi: 10.1002/adhm.202201286. Epub 2022 Aug 26.
Antibiotic hydrogels with sustained release profiles are recognized as promising candidates to treat local bacterial infections with reduced adverse effects. However, it still remains challenging for clinical translation of these antibiotic gels due to safety concern of gel ingredients, complicated synthesis and fabrication procedures, and unsatisfactory rheological properties for practical uses in vivo. Herein, the preparation of a type of sprayable hydrogels by ionic interactions between aminoglycosides and cellulose nanocrystals (CNC) is proposed for the treatment of local infections such as bacteria-infected wounds. The CNC-based hydrogels are applicable for all kinds of aminoglycoside antibiotics and show excellent gel stability and rheological behaviors such as shear thinning and fast self-healing, allowing facile administration by injection or spraying. The hydrogels exhibit efficient antibacterial activity both in vitro and in vivo, and accelerate bacteria-infected wounds by spraying on the infected area. The proposed hydrogels by simply mixing of aminoglycosides and CNC provide great prospects for clinical translation in the treatment of local infections.
具有持续释放特性的抗生素水凝胶被认为是治疗局部细菌感染的有前途的候选药物，可以减少不良反应。然而，由于担心凝胶成分的安全性、复杂的合成和制造工艺以及不理想的流变性能，使其在体内实际应用中受到限制，这些抗生素凝胶的临床转化仍然具有挑战性。本文提出了一种通过氨基糖苷类抗生素与纳米纤维素晶体（CNC）之间的离子相互作用制备可喷涂水凝胶的方法，用于治疗细菌感染等局部感染的伤口。基于 CNC 的水凝胶适用于各种氨基糖苷类抗生素，具有出色的凝胶稳定性和流变性能，如剪切变稀和快速自修复，可通过注射或喷涂进行方便地给药。水凝胶在体外和体内均表现出高效的抗菌活性，并通过喷涂在感染区域加速细菌感染伤口的愈合。通过简单混合氨基糖苷类抗生素和 CNC 制备的水凝胶为局部感染的临床转化提供了广阔的前景。
