From the Pulmonology Department, Laiko General Hospital, Athens, Greece.
From the First Department of Internal Medicine, Laiko General Hospital, Athens, Greece.
Ann Saudi Med. 2022 Jul-Aug;42(4):276-287. doi: 10.5144/0256-4947.2022.276. Epub 2022 Aug 4.
Coronavirus disease 2019 (COVID-19) presents mainly with mild symptoms and involvement of the respiratory system. Acute pancreatitis has also been reported during the course of COVID-19.
Our aim is to review and analyze all reported cases of COVID-19 associated acute pancreatitis, reporting the demographics, clinical characteristics, laboratory and imaging findings, comorbidities and outcomes.
We conducted a systematic search of Pubmed/MEDLINE, SciELO and Google Scholar to identify case reports and case series, reporting COVID-19 associated acute pancreatitis in adults.
There were no ethnicity, gender or language restrictions. The following terms were searched in combination:"COVID-19" OR "SARS-CoV-2" OR "Coronavirus 19" AND "Pancreatic Inflammation" OR "Pancreatitis" OR "Pancreatic Injury" OR "Pancreatic Disease" OR "Pancreatic Damage". Case reports and case series describing COVID-19 associated acute pancreatitis in adults were included. COVID-19 infection was established with testing of nasal and throat swabs using reverse transcription polymerase chain reaction. The diagnosis of acute pancreatitis was confirmed in accordance to the revised criteria of Atlanta classification of the Acute Pancreatitis Classification Working Group. Exclusion of other causes of acute pancreatitis was also required for the selection of the cases.
The following data were extracted from each report: the first author, year of publication, age of the patient, gender, gastrointestinal symptoms due to acute pancreatitis, respiratory-general symptoms, COVID-19 severity, underlying diseases, laboratory findings, imaging features and outcome.
Finally, we identified and analyzed 31 articles (30 case reports and 1 case series of 2 cases), which included 32 cases of COVID-19 induced acute pancreatitis.
COVID-19 associated acute pancreatitis affected mostly females. The median age of the patients was 53.5 years. Concerning laboratory findings, lipase and amylase were greater than three times the ULN while WBC counts and CRP were elevated in the most of the cases. The most frequent gastrointestinal, respiratory and general symptom was abdominal pain, dyspnea and fever, respectively. The most common imaging feature was acute interstitial edematous pancreatitis and the most frequent comorbidity was arterial hypertension while several patients had no medical history. The outcome was favorable despite the fact that most of the patients experienced severe and critical illness.
Our results are limited by the quality and extent of the data in the reports. More specifically, case series and case reports are unchecked, and while they can recommend hypotheses they are not able to confirm robust associations.
None.
新型冠状病毒病 2019（COVID-19）主要表现为轻度症状和呼吸系统受累。在 COVID-19 病程中也有报道发生急性胰腺炎。
我们旨在回顾和分析所有报道的 COVID-19 相关急性胰腺炎病例，报告其人口统计学、临床特征、实验室和影像学发现、合并症和结局。
我们对 Pubmed/MEDLINE、SciELO 和 Google Scholar 进行了系统检索，以确定报告成人 COVID-19 相关急性胰腺炎的病例报告和病例系列。
无种族、性别或语言限制。结合以下术语进行搜索：“COVID-19”或“SARS-CoV-2”或“冠状病毒 19”和“胰腺炎症”或“胰腺炎”或“胰腺损伤”或“胰腺疾病”或“胰腺损伤”。纳入描述成人 COVID-19 相关急性胰腺炎的病例报告和病例系列。使用逆转录聚合酶链反应检测鼻拭子和咽拭子以确定 COVID-19 感染。根据急性胰腺炎分类工作组修订的亚特兰大分类标准，确认急性胰腺炎的诊断。选择病例时还需要排除其他急性胰腺炎的病因。
从每份报告中提取以下数据：第一作者、发表年份、患者年龄、性别、急性胰腺炎引起的胃肠道症状、呼吸-全身症状、COVID-19 严重程度、基础疾病、实验室发现、影像学特征和结局。
最后，我们确定并分析了 31 篇文章（30 篇病例报告和 1 篇 2 例病例系列），其中包括 32 例 COVID-19 引起的急性胰腺炎。
COVID-19 相关急性胰腺炎主要影响女性。患者的中位年龄为 53.5 岁。关于实验室发现，脂肪酶和淀粉酶大于正常值上限的三倍，而白细胞计数和 C 反应蛋白在大多数病例中升高。最常见的胃肠道、呼吸和全身症状分别为腹痛、呼吸困难和发热。最常见的影像学特征是急性间质性水肿性胰腺炎，最常见的合并症是动脉高血压，而一些患者没有既往病史。尽管大多数患者患有严重和危重病，但结局良好。
我们的结果受到报告中数据的质量和范围的限制。具体而言，病例系列和病例报告未经检查，虽然它们可以提出假设，但不能证实可靠的关联。
无。
