Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hengyang Medical School, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan, China.
Health Management Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
J Cell Physiol. 2022 Oct;237(10):3734-3751. doi: 10.1002/jcp.30845. Epub 2022 Aug 7.
Cancer is a disease that seriously endangers human health and is mainly characterized by a high metastasis rate, a high recurrence rate, and a high mortality rate. The treatment of cancer has always been an important research direction of scientific research. A number of studies have shown that the apelin/APJ system is involved in the development and poor prognosis of a variety of cancers, such as lung cancer, liver cancer, cholangiocarcinoma, breast cancer, glioblastoma, prostate cancer, ovarian cancer, and so on. Accumulating evidence has also shown that the apelin/APJ system acts as a biomarker and predictor of postoperative effects in multiple cancers, which can also affect the tumor microenvironment and the efficacy of cancer immunotherapy. Considering that the apelin/APJ system may be a potential target for cancer treatment, it is of great significance for the study of new cancer treatment targets. To better understand the role of the apelin/APJ system on the occurrence and development of cancer, this article reviews the role of the apelin/APJ system in the occurrence and development of various cancers, angiogenesis, tumor stem cells, tumor microenvironment, drug resistance, poor prognosis, and the research progress of related anticancer drugs.
癌症是严重威胁人类健康的疾病，主要特点是转移率高、复发率高、死亡率高。癌症的治疗一直是科研的重要研究方向。有多项研究表明，apelin/APJ 系统参与多种癌症的发生发展和不良预后，如肺癌、肝癌、胆管癌、乳腺癌、胶质母细胞瘤、前列腺癌、卵巢癌等。越来越多的证据表明，apelin/APJ 系统在多种癌症中作为术后效果的生物标志物和预测因子，可以影响肿瘤微环境和癌症免疫治疗的效果。鉴于 apelin/APJ 系统可能是癌症治疗的潜在靶点，这对于研究新的癌症治疗靶点具有重要意义。为了更好地了解 apelin/APJ 系统在癌症发生发展中的作用，本文综述了 apelin/APJ 系统在各种癌症、血管生成、肿瘤干细胞、肿瘤微环境、耐药性、不良预后中的作用，以及相关抗癌药物的研究进展。
