Epidemiology, Biostatistics and Prevention Institute, University of Zurich (UZH), Hirschengraben 84, Zurich 8001, Switzerland; Institute for Implementation Science in Health Care, University of Zurich (UZH), Universitätstrasse 84, Zurich 8006, Switzerland.
Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Mult Scler Relat Disord. 2022 Nov;67:104084. doi: 10.1016/j.msard.2022.104084. Epub 2022 Jul 30.
While comorbidities increase with age, duration of multiple sclerosis (MS) leads to disability accumulation in persons with MS. The influence of ageing vis-a-vis MS duration remains largely unexplored. We studied the independent associations of ageing and MS duration with disability and comorbidities in the Swiss MS Registry participants.
Self-reported data was cross-sectionally analyzed using confounder-adjusted logistic regression models for 6 outcomes: cancer, type 2 diabetes (T2D), hypertension, cardiac diseases, depression, and having at least moderate or severe gait disability. Using cubic splines, we explored non-linear changes in risk shapes.
Among 1615 participants age was associated with cardiac diseases (OR 1.05, 95% CI [1.02, 2.08]), hypertension (OR 1.08, 95% CI [1.06, 2.10]), T2D (OR 1.10, 95%CI [1.05, 1.16]) and cancer (OR 1.04, 95% CI [1.01, 1.07]). MS duration was not associated with comorbidities, except for cardiac diseases (OR 1.03, 95% CI [1.00, 1.06]). MS duration and age were independently associated with having at least moderate gait disability (OR 1.06, 95% CI [1.04, 1.07]; OR 1.04, 95% CI [1.02, 1.05], respectively), and MS duration was associated with severe gait disability (OR 1.05, 95% CI [1.03, 1.08]). The spline analysis suggested a non-linear increase of having at least moderate gait disability with age.
Presence of comorbidities was largely associated with age only. Having at least moderate gait disability was associated with both age and MS duration, while having severe gait disabity was associated with MS duration only.
随着年龄的增长，合并症会增加，而多发性硬化症（MS）的病程会导致 MS 患者的残疾积累。年龄与 MS 病程对残疾和合并症的影响在很大程度上仍未得到探索。我们在瑞士 MS 登记处参与者中研究了年龄和 MS 病程与残疾和合并症的独立关联。
使用混杂因素调整的逻辑回归模型，对 6 项结果进行了横断面分析：癌症、2 型糖尿病（T2D）、高血压、心脏病、抑郁症和至少中度或重度步态残疾。使用三次样条，我们探索了风险形状的非线性变化。
在 1615 名参与者中，年龄与心脏病（OR 1.05，95%CI [1.02，2.08]）、高血压（OR 1.08，95%CI [1.06，2.10]）、T2D（OR 1.10，95%CI [1.05，1.16]）和癌症（OR 1.04，95%CI [1.01，1.07]）有关。MS 病程与合并症无关，但与心脏病有关（OR 1.03，95%CI [1.00，1.06]）。MS 病程和年龄与至少中度步态残疾独立相关（OR 1.06，95%CI [1.04，1.07]；OR 1.04，95%CI [1.02，1.05]），MS 病程与严重步态残疾相关（OR 1.05，95%CI [1.03，1.08]）。样条分析表明，年龄与至少中度步态残疾的增加呈非线性关系。
合并症的存在主要与年龄有关。至少中度步态残疾与年龄和 MS 病程有关，而严重步态残疾仅与 MS 病程有关。
