Sorokina I B, Khasman E L, Gor'kova N P, Uchitel' I Ia
Biull Eksp Biol Med. 1980 Apr;89(4):449-52.
Blastolysin consisting largely of glycopeptide fragments of cell walls from Lactobacillus bulgaricus has a significant antineoplastic activity against a number of transplanted and spontaneous animal tumours. Blastolysin exerts a pronounced adjuvant action and activates the cells of the mononuclear phagocytic system. This is shown by stimulation of phagocytosis and digestion as well as by acquired ability of macrophages to elicit a cytotoxic action on allogeneic and syngeneic target cells (labelled with radioactive chromium) with abnormal growth. Administration of blastolysin or BCG was demonstrated to lead to variations in the time course of macrophage acquired cytotoxicity. Macrophage activation induced by blastolysin has a clearly pronounced two-phasic nature. During the first short phase the cytotoxicity is seen 2 hours following blastolysin administration, rapidly disappears and emerges after 2 weeks, remaining unchanged up to the 5th week (experimental period).
主要由保加利亚乳杆菌细胞壁糖肽片段组成的溶菌素对多种移植性和自发性动物肿瘤具有显著的抗肿瘤活性。溶菌素具有明显的佐剂作用，并能激活单核吞噬系统的细胞。这表现为吞噬作用和消化作用的增强，以及巨噬细胞获得对生长异常的同种异体和同基因靶细胞（用放射性铬标记）产生细胞毒性作用的能力。已证明给予溶菌素或卡介苗会导致巨噬细胞获得性细胞毒性的时间进程发生变化。溶菌素诱导的巨噬细胞活化具有明显的双相性。在第一个短阶段，给药后2小时可见细胞毒性，迅速消失，2周后出现，并在第5周（实验期）前保持不变。
