Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; University Hospital Montpellier, Montpellier, France; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany.
Public Health, Aix-Marseille University, Marseille, France.
J Allergy Clin Immunol Pract. 2022 Nov;10(11):2878-2888. doi: 10.1016/j.jaip.2022.07.020. Epub 2022 Aug 4.
Drug repurposing is a major field of value-added medicine. It involves investigating and evaluating existing drugs for new therapeutic purposes that address unmet healthcare needs. Several unmet needs in allergic rhinitis could be improved by drug repurposing. This could be game-changing for disease management. Current medications for allergic rhinitis are centered on continuous long-term treatment, and medication registration is based on randomized controlled trials carried out for a minimum of 14 days with adherence of 70% or greater. A new way of treating allergic rhinitis is to propose as-needed treatment depending on symptoms, rather than classical continuous treatment. This rostrum will discuss existing clinical trials on as-needed treatment for allergic rhinitis and real-world data obtained by the mobile health app MASK-air, which focuses on digitally-enabled, patient-centered care pathways.
药物再利用是增值医学的一个主要领域。它涉及研究和评估现有药物的新治疗用途,以满足未满足的医疗保健需求。药物再利用可以改善过敏鼻炎的一些未满足需求。这可能会改变疾病的管理方式。目前治疗过敏鼻炎的药物主要是持续的长期治疗,药物注册是基于至少 14 天、70%或更高的依从性的随机对照试验。一种新的治疗过敏鼻炎的方法是根据症状提出按需治疗,而不是经典的持续治疗。本次演讲将讨论过敏鼻炎按需治疗的现有临床试验,以及专注于数字化、以患者为中心的护理途径的移动健康应用 MASK-air 获得的真实世界数据。