Department of Otorhinolaryngology, University of Pennsylvania, 3737 Market Street, Suite 302, Philadelphia, PA 19104, USA.
Georgia Center for Facial Plastic Surgery, 613 Ponder Place Drive, Evans, GA 30809, USA.
Facial Plast Surg Clin North Am. 2022 Aug;30(3):301-308. doi: 10.1016/j.fsc.2022.03.004.
Hyaluronic acid (HA) is the most common dermal filler in use. It improves wrinkles and volume loss not only by filling and volumizing but also by hydrating the injected area with its water affinity. It is a naturally occurring component of skin, and there is a negligible risk of immunologic or allergic reaction with injection. It is rapidly degraded by the injection of hyaluronidase, thus creating an ideal injectable material that is low risk and reversible. Its duration of effect may be longer than expected based on bioavailability of the HA product due to collagen synthesis or fibroblast stimulation.
透明质酸（HA）是最常用的真皮填充剂。它不仅通过填充和增容来改善皱纹和体积损失，还通过其亲水性来滋润注射区域。它是皮肤中天然存在的成分，注射时几乎没有免疫或过敏反应的风险。通过注射透明质酸酶，它会迅速降解，从而产生一种低风险、可逆转的理想注射材料。由于胶原蛋白合成或成纤维细胞刺激，其作用持续时间可能比基于 HA 产品的生物利用度预期的时间更长。
