Ling Yang, Liu Xinhao, Yang E
Department of Dermatology, The People's Hospital of Wansheng District, Chongqing, China.
Department of Burn and Plastic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
J Cosmet Dermatol. 2025 Jun;24(6):e70286. doi: 10.1111/jocd.70286.
To study the safety and clinical effect of PRP combined with hyaluronic acid (HA) mesotherapy in the treatment of facial chloasma, to explore a safe and effective treatment option for chloasma.
57 patients with chloasma who received mesotherapy were analyzed in this study. They were divided into 19 cases of the PRP combined with HA mesotherapy group (PRP+HA group), 20 cases of the PRP mesotherapy group (PRP group) and 18 cases of the hyaluronic acid mesotherapy group (HA group). The therapeutic effect of chloasma was evaluated at the fourth week after treatment, including the decrease rate of chloasma area and severity index (MASI), the effective rate, the decrease rate of pigment degree, the decrease rate of pigment area, and the decrease rate of pigment quantity. The patient's satisfaction and adverse reactions were investigated. The safety and efficacy of each group were compared and analyzed.
The effective rate of chloasma treatment in the PRP group and the PRP+HA group was more than 50% at 4 weeks after treatment. The improvement of the above indexes in the PRP+HA group was better than those in the single treatment group. The satisfaction of the PRP+HA group was higher than that of the HA group, and the satisfaction of the other groups was not significantly different. There were no serious adverse reactions in the three groups.
PRP mesotherapy alone or combined with HA and PRP mesotherapy can effectively treat chloasma, and the combined treatment effect is better, which is worthy of clinical promotion.
研究富血小板血浆（PRP）联合透明质酸（HA）中胚层疗法治疗面部黄褐斑的安全性及临床效果，探索一种安全有效的黄褐斑治疗方案。
本研究分析了57例接受中胚层疗法治疗的黄褐斑患者。将其分为PRP联合HA中胚层疗法组19例（PRP+HA组）、PRP中胚层疗法组20例（PRP组）和透明质酸中胚层疗法组18例（HA组）。在治疗后第4周评估黄褐斑的治疗效果，包括黄褐斑面积减少率和严重程度指数（MASI）、有效率、色素程度降低率、色素面积降低率和色素量降低率。调查患者满意度及不良反应。对各组的安全性和疗效进行比较分析。
治疗后4周，PRP组和PRP+HA组黄褐斑治疗有效率均超过50%。PRP+HA组上述指标的改善情况优于单一治疗组。PRP+HA组的满意度高于HA组，其他组之间满意度差异无统计学意义。三组均未出现严重不良反应。
单独应用PRP中胚层疗法或联合HA及PRP中胚层疗法均可有效治疗黄褐斑，联合治疗效果更佳，值得临床推广。
