Sadighara Parisa, Mahdavi Vahideh, Tahmasebi Rahele, Saatloo Naiema Vakili
Department of Environmental Health, Food Safety Division, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Iranian Research Institute of Plant Protection (IRIPP), Agricultural Research, Education and Extension Organization (AREEO), Tehran, Iran.
Rev Environ Health. 2022 Aug 8;38(4):621-627. doi: 10.1515/reveh-2022-0035. Print 2023 Dec 15.
Due to the widespread use and environmental pollution of estrogenic chemicals, the need for screening tests to detect these compounds is felt more than ever. These compounds lead to cell proliferation. Therefore, studies used cell proliferation to evaluate estrogenic compounds was studied in this systematic review. This systematic review was performed with the keywords; DNA proliferation, cell proliferation, estrogenic component, estrogen, food, bioassay, screening, and detection. After initial screening and full text quality assessment, 16 manuscripts were selected and data were extracted. Four cell lines, MCF-7, MDA-MB-231, Ishikawa, and T47D cells were used in the studies. MCF-7 was more sensitive to estrogenic compounds than other lines. Most of the samples studied were plant compounds and mycotoxins and substances that migrate from packaging to food. This screening test is valid and has similar results as others.
由于雌激素类化学物质的广泛使用和环境污染，对检测这些化合物的筛查试验的需求比以往任何时候都更强烈。这些化合物会导致细胞增殖。因此，本系统评价研究了利用细胞增殖来评估雌激素类化合物的研究。本系统评价使用了以下关键词进行：DNA增殖、细胞增殖、雌激素成分、雌激素、食物、生物测定、筛查和检测。经过初步筛选和全文质量评估，选择了16篇手稿并提取了数据。研究中使用了四种细胞系，MCF-7、MDA-MB-231、石川细胞和T47D细胞。MCF-7对雌激素类化合物比其他细胞系更敏感。研究的大多数样品是植物化合物、霉菌毒素以及从包装迁移到食物中的物质。这种筛查试验是有效的，并且与其他试验结果相似。
