Ghahremani Mohammad-Hossein, Ghazi-Khansari Mahmoud, Farsi Zahra, Yazdanfar Najmeh, Jahanbakhsh Mahadi, Sadighara Parisa
Department of Toxicology & Pharmacology, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Food Chem X. 2024 Jan 17;21:101142. doi: 10.1016/j.fochx.2024.101142. eCollection 2024 Mar 30.
This systematic study deals with the amount of bisphenol A (BPA) in milk and dairy products, its analytical methods, and risk assessment. Milk is one of the drinks that has a high consumption. Bisphenol A can be present both in raw milk and its amount undergoes changes during the pasteurization process. This review was conducted by searching for the keywords Bisphenol A, BPA milk, dairy product, cheese, cream, butter, yogurt, measurement, detection, and analysis in different databases. The search was done in three databases, Scopus, PubMed and Science Direct. The largest number of studies on the determination of bisphenol A belonged to Asian and European countries. The amount of bisphenol A in milks was observed in the range from ND to 640 ng/mL. Furthermore, the amount of BPA in the tested cheese samples was observed in the ND range up to 6.1 ng/g and in the yogurt samples in the ND range up to 4.4 ng/g. The most used analytical method was based on liquid chromatography. The most used solvent for extraction was methanol or acetonitrile. HQ (Hazard Quotient) was also calculated in some studies. There was no risk in terms of milk consumption due to BPA contamination in extracted data.
这项系统性研究涉及牛奶和乳制品中双酚A（BPA）的含量、其分析方法以及风险评估。牛奶是消费量很大的饮品之一。双酚A可存在于生牛奶中，且其含量在巴氏杀菌过程中会发生变化。本综述通过在不同数据库中搜索关键词双酚A、BPA牛奶、乳制品、奶酪、奶油、黄油、酸奶、测量、检测和分析来进行。搜索在三个数据库，即Scopus、PubMed和ScienceDirect中进行。关于双酚A测定的研究数量最多的是亚洲和欧洲国家。牛奶中双酚A的含量在未检出（ND）至640纳克/毫升的范围内。此外，在测试的奶酪样品中，双酚A的含量在未检出至6.1纳克/克的范围内，在酸奶样品中则在未检出至4.4纳克/克的范围内。最常用的分析方法基于液相色谱法。最常用的萃取溶剂是甲醇或乙腈。在一些研究中还计算了危害商数（HQ）。根据提取的数据，因BPA污染而导致的牛奶消费不存在风险。
