Department of Urology, Suzhou Hospital of Anhui Medical University, Suzhou, China.
Andrologia. 2022 Nov;54(10):e14550. doi: 10.1111/and.14550. Epub 2022 Aug 7.
Prostate cancer (PCa) is one of the most prevalent tumours of the male genitourinary system in the world. In recent years, the morbidity of PCa is steadily rising annually in China. Prostate cancer is prone to distant metastasis, and the most significant complication among patients with advanced PCa is bone metastases. Most patients with prostate cancer do not die of the primary tumour, but more due to the factors of distant metastasis of organs, especially bone metastasis. Due to the lack of effective prevention and monitoring of bone metastasis of PCa in clinical settings, and the lack of effective treatment for patients with bone metastasis, the prognosis of patients is often poor. Therefore, early prevention, early detection, and inhibition of bone metastasis are particularly important. At present, many studies have found that exosomes and integrins are closely related to bone metastasis of prostate cancer, but they have not been summarized together. This review summarizes the literature on the effects of exosomes and integrins on bone metastasis of prostate cancer in recent years. It aims to find more effective ways to prevent, monitor, and treat prostate cancer from the relationship between them.
前列腺癌（PCa）是全球男性泌尿生殖系统中最常见的肿瘤之一。近年来，中国 PCa 的发病率每年稳步上升。前列腺癌易发生远处转移，晚期 PCa 患者最常见的并发症是骨转移。大多数前列腺癌患者并非死于原发性肿瘤，而是更多地由于远处转移器官的因素，尤其是骨转移。由于临床环境中缺乏对 PCa 骨转移的有效预防和监测，以及对骨转移患者缺乏有效治疗，患者的预后往往较差。因此，早期预防、早期发现和抑制骨转移尤为重要。目前，许多研究发现外泌体和整合素与前列腺癌骨转移密切相关，但尚未将它们总结在一起。本综述总结了近年来关于外泌体和整合素对前列腺癌骨转移影响的文献，旨在从它们之间的关系中找到更有效的预防、监测和治疗前列腺癌的方法。
