Teta M J, Ott M G, Schnatter A R
Br J Ind Med. 1987 May;44(5):344-50. doi: 10.1136/oem.44.5.344.
The utility of a population based, corporate wide mortality surveillance system was evaluated after a 10 year observation period of one of the company's divisions. The subject population, 2219 white male, long term employees from Union Carbide Corporation's carbon based electrode and specialty products operations, was followed up for mortality from 1974 to 1983. External comparisons with the United States male population were supplemented with internal comparisons among subgroups of the study population, defined by broad job categories and time related variables, adjusting for important correlates of the healthy worker effect. Significant deficits of deaths were observed for all causes and the major non-cancer causes of death. The numbers of deaths due to malignant neoplasms and respiratory cancer were less than, but not statistically different from, expected. There was a non-significant excess of deaths from lymphopoietic cancer, occurring predominantly among salaried employees. When specific locations were examined, operations with potential exposure to coal tar products exhibited a mortality pattern similar to that of the total cohort. The risk for lung cancer was significantly raised (five observed, 1.4 expected) in one small, but older, location which did not involve coal tar products during the period of employment of these individuals, but which historically used asbestos materials for several unique applications. Although these findings are limited by small numbers and a short observation period, the population based surveillance strategy has provided valuable information regarding the mortality experience of the population, directions for future research, and the allocation of epidemiological resources.
在对该公司一个部门进行了10年观察期后,对基于全公司人口的死亡率监测系统的效用进行了评估。研究对象为联合碳化物公司碳基电极及特种产品业务部门的2219名长期在职白人男性员工,对其1974年至1983年期间的死亡率进行了随访。除了与美国男性人口进行外部比较外,还对研究人群的亚组进行了内部比较,亚组由宽泛的工作类别和与时间相关的变量定义,并对健康工人效应的重要相关因素进行了调整。观察到所有死因和主要非癌症死因的死亡人数均显著不足。恶性肿瘤和呼吸道癌症导致的死亡人数低于预期,但无统计学差异。淋巴细胞性癌症导致的死亡人数有非显著性增加,主要发生在受薪员工中。在检查特定地点时,有可能接触煤焦油产品的业务部门的死亡率模式与整个队列相似。在一个规模较小但较老的地点,肺癌风险显著升高(观察到5例,预期1.4例),在这些人的就业期间该地点不涉及煤焦油产品,但历史上曾将石棉材料用于一些独特用途。尽管这些发现因样本数量少和观察期短而受到限制,但基于人群的监测策略提供了有关该人群死亡率情况、未来研究方向以及流行病学资源分配的有价值信息。