Tang A-Ling, Peng Yu, Shen Mei-Jia, Liu Xiao-Yu, Li Shan, Xiong Meng-Chen, Gao Nan, Hu Tian-Peng, Zhang Guo-Qiang
Graduate School, Beijing University of Chinese Medicine, Beijing, China.
Department of Emergency, China-Japan Friendship Hospital, Beijing, China.
Front Physiol. 2022 Jul 22;13:941257. doi: 10.3389/fphys.2022.941257. eCollection 2022.
The incidence and mortality of sepsis are increasing year by year, and there is still a lack of specific biomarkers to predict its prognosis. Prognostic value of vascular endothelial growth factor (VEGF) in predicting the severity and mortality of sepsis has been gradually discovered. Literature was searched through Embase, PubMed, Web of Science, China National Knowledge Infrastructure(CNKI) and Cochrane Library databases in March 2022. Observational studies, evaluating the impact of VEGF in sepsis outcomes (mortality and severity) are included in this meta-analysis. Risk of bias was assessed with the Newcastle-Ottawa Scale (NOS). Sensitivity and publication bias analyses were also assessed. Meta-regression analysis were performed to identify the potential sources of heterogeneity. A total of 1,574 articles were retrieved from the systematic literature search. We included 20 studies for qualitative and quantitative analysis. Deceased and critically ill patients had higher baseline VEGF levels than survivors and non-severe patients. The pooled sensitivity and specificity for VEGF predicts sepsis mortality were 0.79and 0.76, respectively. the area under the SROC curve was 0.83. High VEGF are associated with poor clinical outcomes for patients diagnosed with sepsis. This study was recorded on PROSPERO, under the registration ID: CRD42022323079.
脓毒症的发病率和死亡率逐年上升，目前仍缺乏预测其预后的特异性生物标志物。血管内皮生长因子（VEGF）在预测脓毒症严重程度和死亡率方面的预后价值已逐渐被发现。2022年3月，通过Embase、PubMed、Web of Science、中国知网（CNKI）和Cochrane图书馆数据库进行文献检索。本荟萃分析纳入了评估VEGF对脓毒症结局（死亡率和严重程度）影响的观察性研究。采用纽卡斯尔-渥太华量表（NOS）评估偏倚风险。还进行了敏感性和发表偏倚分析。进行荟萃回归分析以确定异质性的潜在来源。通过系统文献检索共检索到1574篇文章。我们纳入了20项研究进行定性和定量分析。死亡和重症患者的基线VEGF水平高于幸存者和非重症患者。VEGF预测脓毒症死亡率的合并敏感性和特异性分别为0.79和0.76。SROC曲线下面积为0.83。高VEGF水平与脓毒症诊断患者的不良临床结局相关。本研究已在PROSPERO上注册，注册号为：CRD42022323079。
