Department of Chemistry & Biochemistry, School of Green Chemistry and Engineering, The University of Toledo, 2801 W. Bancroft St., Mailstop 602, Toledo, OH 43606, USA.
Org Biomol Chem. 2022 Aug 24;20(33):6646-6653. doi: 10.1039/d2ob01171a.
Herein we describe a method for combining supramolecular catalysis with imininum-based organocatalysis in the Diels-Alder cycloaddition reaction. Both supramolecular host and L-proline are required for the reaction to occur, implying that encapsulation of the substrates and co-catalyst are necessary for the reaction to occur. We explore the substrate scope for a variety of -cinnamaldehydes and dienes. Finally, we probe the supramolecular assembly processes responsible for the observed catalysis using NMR spectroscopic methods.
在此，我们描述了一种在 Diels-Alder 环加成反应中将超分子催化与亚氨基基有机催化相结合的方法。反应需要超分子主体和 L-脯氨酸，这意味着反应需要对底物和共催化剂进行封装。我们探索了各种肉桂醛和二烯的底物范围。最后，我们使用 NMR 光谱方法探究了负责观察到的催化的超分子组装过程。
