Department of Chemistry, The University of Tokyo, Tokyo, Japan.
Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan.
Cytometry A. 2023 Feb;103(2):162-167. doi: 10.1002/cyto.a.24677. Epub 2022 Aug 8.
There is a global concern about the safety of COVID-19 vaccines associated with platelet function. However, their long-term effects on overall platelet activity remain poorly understood. Here we address this problem by image-based single-cell profiling and temporal monitoring of circulating platelet aggregates in the blood of healthy human subjects, before and after they received multiple Pfizer-BioNTech (BNT162b2) vaccine doses over a time span of nearly 1 year. Results show no significant or persisting platelet aggregation trends following the vaccine doses, indicating that any effects of vaccinations on platelet turnover, platelet activation, platelet aggregation, and platelet-leukocyte interaction was insignificant.
人们普遍关注与血小板功能相关的 COVID-19 疫苗的安全性。然而，它们对整体血小板活性的长期影响仍知之甚少。在这里，我们通过基于图像的单细胞分析，并在健康人体血液中对循环血小板聚集体进行时间监测，解决了这个问题，这些人在将近 1 年的时间里接受了多次辉瑞-生物科技（BNT162b2）疫苗接种。结果表明，疫苗接种后没有明显或持续的血小板聚集趋势，这表明接种疫苗对血小板更新、血小板激活、血小板聚集和血小板-白细胞相互作用没有显著影响。
