[Distribution of the 14C-hydrated analog of phenazepam in the organs and tissues of mice].
作者信息
Golovenko N Ia, Sozinov V A, Rudenko O P
出版信息
Biull Eksp Biol Med. 1986 Mar;101(3):327-9.
PMID:2869800
Abstract
The absorption kinetics of hydrated phenazepam analog into the liver, spleen, brain, kidney, blood, lungs, heart, skeletal and fat tissues is studied at 0.25-24 hour intervals after its intraperitoneal (i/p) administration to mice. Drug concentration in the above mentioned organs was maximal 0.5-1 hour later. The decrease of the drug and its metabolite level in the organs under study is a biexponential process, consisting of "quick" (1-6 hours) and "slow" phases. The rate of absorption of hydrated phenazepam analog into the organs and tissues and its elimination is lower than that of phenanzepam.
摘要
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