Khan Haseeb Ahmed, Haseeb Khan Sana, Tayyab Zaid, Saif Saba, Khan Saima N, Musaddiq Sana
Rheumatology, Dorset County Hospital, Dorchester, GBR.
Hematology, Al Aleem Medical College, Lahore, PAK.
Cureus. 2024 Mar 25;16(3):e56908. doi: 10.7759/cureus.56908. eCollection 2024 Mar.
The inner layer of the synovial joints is the primary target of rheumatoid arthritis, or RA, a chronic systemic inflammatory disorder that is linked to increasing disability, early mortality, and economic hardships. The objective is to determine the association of red cell distribution width (RDW) and mean platelet volume (MPV) with disease activity in RA.
A retrospective study was conducted between July 2021 and January 2022 in the outpatient rheumatology clinics at Gulab Devi Teaching Hospital. In this study, 100 consecutive participants with a diagnosis of RA fulfilling the ACR/EULAR 2010 classification criteria were enrolled. Patient's records were reviewed for age, gender, length of illness, smoking status, treatment history, current treatment regimen, concomitant medications, rheumatoid factor (RF), anti-cyclic citrulline peptide (anti-CCP) antibodies, and extra-articular manifestations. Laboratory investigations were reviewed for complete blood count including RDW and MPV, ESR, CRP, liver, and renal functions. Disease activity score DAS 28-ESR was used to quantify disease activity. To determine the relationship between different parameters and the RDW and MPV, linear regression research was conducted.
According to the DAS28 score, 12% of patients were in remission, 9% had low, 34% had moderate, and 45% had high disease activity. DAS28 score was 5.01±1.72 (2.45-9.32) and RDW was 16.18±4.42. There was a strong positive correlation (r = 0.653) of RDW with the DAS28 score and it was statistically significant (p<0.001). MPV was 11.30±2.09 fL. There was a moderately positive correlation (r = 0.366) of MPV with the DAS28 score and it was statistically significant (p<0.001).
Conclusively, both RDW and MPV are positively related to disease activity in patients with RA. These can be used as a simple tool for assessing disease activity and guiding the treatment.
滑膜关节的内层是类风湿关节炎（RA）的主要靶点，RA是一种慢性全身性炎症性疾病，与残疾增加、早期死亡和经济困难有关。目的是确定红细胞分布宽度（RDW）和平均血小板体积（MPV）与RA疾病活动度之间的关联。
2021年7月至2022年1月在古拉布·德维教学医院的门诊风湿病诊所进行了一项回顾性研究。在本研究中，连续纳入100例符合美国风湿病学会/欧洲抗风湿病联盟2010分类标准的RA诊断患者。查阅患者记录，了解其年龄、性别、病程、吸烟状况、治疗史、当前治疗方案、合并用药、类风湿因子（RF）、抗环瓜氨酸肽（抗CCP）抗体和关节外表现。查阅实验室检查结果，包括全血细胞计数（包括RDW和MPV）、红细胞沉降率（ESR）、C反应蛋白（CRP）、肝功能和肾功能。采用疾病活动度评分DAS28-ESR来量化疾病活动度。为了确定不同参数与RDW和MPV之间的关系，进行了线性回归研究。
根据DAS28评分，12%的患者处于缓解期，9%的患者疾病活动度低，3^%的患者疾病活动度中等，45%的患者疾病活动度高。DAS28评分为5.01±1.72（2.45 - 9.^2），RDW为16.18±4.42。RDW与DAS28评分呈强正相关（r = 0.653），且具有统计学意义（p<^.001）。MPV为11.30±2.09 fL。MPV与DAS28评分呈中度正相关（r = 0.366），且具有统计学意义（p<^.001）。
总之，RDW和MPV均与RA患者的疾病活动度呈正相关。这些指标可作为评估疾病活动度和指导治疗的简单工具。
