Xu Jiang, Kerr Liam, Jiang Yue, Suo Wenhao, Zhang Lei, Lao Taotao, Chen Yuxin, Zhang Yan
Department of Systems Biology Blavatnik Institute Harvard Medical School Boston MA 02115 USA.
Department of Molecular Virology Virogin Biotech Ltd. 3800 Wesbrook Mall Vancouver BC V6S 2L9 Canada.
Small Sci. 2022 Aug;2(8):2200009. doi: 10.1002/smsc.202200009. Epub 2022 Jul 5.
The ongoing global COVID-19 pandemic, caused by the SARS-CoV-2 virus, has resulted in significant loss of life since December 2019. Timely and precise virus detection has been proven as an effective solution to reduce the spread of the virus and to track the epidemic. Rapid antigen diagnostics has played a significant role in the frontline of COVID-19 testing because of its convenience, low cost, and high accuracy. Herein, different types of recently innovated in-lab and commercial antigen diagnostic technologies with emphasis on the strengths and limitations of these technologies including the limit of detection, sensitivity, specificity, affordability, and usability are systematically reviewed. The perspectives of assay development are looked into.
自2019年12月以来，由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的全球新冠疫情已导致大量人员死亡。及时、准确的病毒检测已被证明是减少病毒传播和追踪疫情的有效解决方案。快速抗原诊断因其便利性、低成本和高准确性，在新冠检测的前线发挥了重要作用。本文系统综述了近期创新的不同类型的实验室和商业抗原诊断技术，重点阐述了这些技术的优势和局限性，包括检测限、灵敏度、特异性、可负担性和可用性。同时探讨了检测方法的发展前景。
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