血液透析患者中可溶性 Klotho 水平与贫血及血红蛋白变异性的关联。
The association of soluble Klotho levels with anemia and hemoglobin variability in hemodialysis patients.
作者信息
Topal Mustafa, Guney Ibrahim
机构信息
Clinic of Nephrology, Konya City Hospital, University of Health Sciences, Konya, Turkey.
出版信息
Semin Dial. 2023 Mar;36(2):142-146. doi: 10.1111/sdi.13122. Epub 2022 Aug 9.
INTRODUCTION
The anti-aging protein Klotho levels are decreased, and Klotho deficiency is associated with cardiovascular diseases in patients with chronic kidney disease. There are recent studies about the relation between soluble Klotho levels and anemia. We aimed to investigate the correlation of anemia and hemoglobin variability with soluble Klotho levels in hemodialysis patients.
METHODS
Ninety-one hemodialysis patients were included in this study. The mean hemoglobin value, hemoglobin variability, and coefficient of variation of hemoglobin for each patient were calculated. According to mean hemoglobin levels, two groups were defined as under 11 and ≥11 g/dl. Soluble Klotho levels of each patient were studied.
RESULTS
Mean hemoglobin levels, hemoglobin variability, and coefficient of variation of hemoglobin were not significantly correlated with soluble Klotho levels. According to mean hemoglobin levels under 11 and ≥ 11 g/dl, there was no statistically significant correlation between anemia and soluble Klotho levels.
CONCLUSION
Soluble Klotho levels were not associated with anemia and hemoglobin variability in hemodialysis patients. Further studies are needed to reveal the complicated relation between anemia and soluble Klotho levels.
引言
抗衰蛋白α-klotho水平降低，且α-klotho缺乏与慢性肾脏病患者的心血管疾病相关。近期有关于可溶性α-klotho水平与贫血之间关系的研究。我们旨在探讨血液透析患者贫血及血红蛋白变异性与可溶性α-klotho水平的相关性。
方法
本研究纳入91例血液透析患者。计算每位患者的平均血红蛋白值、血红蛋白变异性及血红蛋白变异系数。根据平均血红蛋白水平，将两组定义为低于11 g/dl和≥11 g/dl。研究每位患者的可溶性α-klotho水平。
结果
平均血红蛋白水平、血红蛋白变异性及血红蛋白变异系数与可溶性α-klotho水平无显著相关性。根据平均血红蛋白水平低于11 g/dl和≥11 g/dl，贫血与可溶性α-klotho水平之间无统计学显著相关性。
结论
血液透析患者的可溶性α-klotho水平与贫血及血红蛋白变异性无关。需要进一步研究以揭示贫血与可溶性α-klotho水平之间的复杂关系。
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