Hunter R E, Longcope C, Keough P
Cancer. 1987 Aug 1;60(3):392-6. doi: 10.1002/1097-0142(19870801)60:3<392::aid-cncr2820600318>3.0.co;2-c.
To correlate the presence of specific steroid receptors with certain characteristics of cervical carcinoma, cytosol estrogen receptors (ERc) were measured in 70 cases of cervical carcinoma, and progesterone receptors (PRc) were measured in 56 of these cases; ERc and PRc were also measured in 17 normal cervices. Measurements were made using a dextran-coated charcoal technique involving a seven-point Scatchard plot analysis. In carcinoma of the cervix significant numbers of ERc (greater than 3 fmol/mg protein) were found in 41% of the cases, and of PRc (greater than 3 fmol/mg protein) in 30%; only 28% of the 56 cases contained both ERc and PRc. In the normal cervices, 59% contained significant levels of ERc and 41% significant levels of PRc. No correlation was found between ERc and PRc and menopausal status of the patient, stage, cell type, or histologic grade of the tumor. A weak (P = 0.063) correlation between the presence of PRc and length of survival was also found, but there was no correlation between ERc and survival. Unlike the situation for breast cancer, measurement of ERc and PRc appears to add little of value to the clinical management of cervical carcinoma.
为了将特定类固醇受体的存在与宫颈癌的某些特征相关联，对70例宫颈癌患者测定了胞浆雌激素受体（ERc），并对其中56例测定了孕激素受体（PRc）；同时对17例正常宫颈组织也进行了ERc和PRc测定。采用葡聚糖包被活性炭技术并通过七点Scatchard图分析进行测量。在宫颈癌病例中，41%的病例发现有大量ERc（大于3 fmol/mg蛋白），30%的病例发现有大量PRc（大于3 fmol/mg蛋白）；在56例病例中，只有28%同时含有ERc和PRc。在正常宫颈组织中，59%含有显著水平的ERc，41%含有显著水平的PRc。未发现ERc和PRc与患者的绝经状态、肿瘤分期、细胞类型或组织学分级之间存在相关性。还发现PRc的存在与生存期之间存在弱相关性（P = 0.063），但ERc与生存期之间无相关性。与乳腺癌的情况不同，测定ERc和PRc对宫颈癌的临床管理似乎没有太大价值。
