Potish R A, Twiggs L B, Adcock L L, Prem K A, Savage J E, Leung B S
Cancer. 1986 Oct 15;58(8):1709-13. doi: 10.1002/1097-0142(19861015)58:8<1709::aid-cncr2820580822>3.0.co;2-b.
Tissue levels of cytosolic estrogen receptors (ERc) and progesterone receptors (PRc) have been shown to have prognostic meaning in hormonally responsive cancers arising in the breast and endometrium. Although carcinomas of the uterine cervix rarely respond to hormonal manipulation, the normal cervical stroma and epithelia contain ERc and PRc. To study the prognostic value of these receptors, 65 cervical carcinomas for ERc and PRc were assayed before initiation of surgical or radiation therapy. In premenopausal women, logistic models demonstrated that clinical stage, surgical stage, and receptor level independently predict survival. If confirmed in further studies, ERc and PRc may prove to be useful prognostic factors in the management of cervical carcinomas.
细胞溶质雌激素受体（ERc）和孕激素受体（PRc）的组织水平已被证明在乳腺和子宫内膜发生的激素反应性癌症中具有预后意义。虽然子宫颈癌很少对激素治疗有反应，但正常宫颈基质和上皮含有ERc和PRc。为了研究这些受体的预后价值，在开始手术或放疗前，对65例宫颈癌进行了ERc和PRc检测。在绝经前女性中，逻辑模型表明临床分期、手术分期和受体水平可独立预测生存率。如果在进一步研究中得到证实，ERc和PRc可能被证明是宫颈癌治疗中有用的预后因素。
