利用 PowerPlex® fusion 系统对巴基斯坦开伯尔-普赫图赫瓦省、俾路支省和吉尔吉特-巴尔蒂斯坦地区的 22 个常染色体 STR 基因座的遗传数据进行分析。
Genetic data of 22 autosomal STR loci in Khyber-Pakhtunkhwa, Balochistan and Gilgit Baltistan population of Pakistan using PowerPlex® fusion system.
机构信息
Forensic DNA Typing Laboratory, Centre of Excellence in Molecular Biology, University of the Punjab Lahore 53700, Pakistan.
Faculty of Life Sciences and Informatics, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta (BAUITEMS), Pakistan.
出版信息
Leg Med (Tokyo). 2022 Nov;59:102129. doi: 10.1016/j.legalmed.2022.102129. Epub 2022 Aug 3.
In this study we have provided forensic genetic data of 22 autosomal STRs for Pakhtun, Balochi and Balti population of Pakistan in total of 601 samples. Among these loci, Penta E was found the most discriminatory in all groups and allele 15 was observed most frequent at D22S1045 in Balti whereas in other two populations allele 8 was more common at TPOX. The combined power of discrimination, combined power of exclusion and the combined matching probability was calculated as 0.999999999999999999999999998385, 0.999999988089728 and 1.615 × 10 respectively. Based on population differentiation test, significant differences were observed when compared with other populations however, phylogenetic analysis revealed close genetic associations among Pakistani Populations.
在这项研究中，我们提供了来自巴基斯坦普什图人、俾路支人和巴尔蒂人共 601 个样本的 22 个常染色体 STR 的法医学遗传数据。在这些基因座中，Penta E 在所有群体中表现出最高的区分度，而在巴尔蒂人群体中，D22S1045 上的等位基因 15 观察到最频繁，而在其他两个群体中，TPOX 上的等位基因 8 更为常见。计算得出的组合判别力、组合排除力和组合匹配概率分别为 0.99999999999999999999999998385、0.999999988089728 和 1.615×10。基于种群分化测试，与其他种群相比观察到显著差异，但系统发生分析显示巴基斯坦种群之间存在密切的遗传关联。
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