Key Laboratory of Epigenetics and Oncology, The Research Center for Preclinical Medicine, Southwest Medical University, Luzhou 646000, China.
Laboratory of Forensic DNA, The Judicial Authentication Center, Southwest Medical University, Luzhou 646000, China.
Genes (Basel). 2023 Jul 9;14(7):1419. doi: 10.3390/genes14071419.
The Han nationality is an ancient and populous people, and different places in China may have their distinct group relationships. Luzhou area, as a crossroads of several provinces in Southwest China, lacks autosomal short tandem repeat (STR) research and population genetics research. In this study, 21 autosomal STR loci were evaluated in 1959 Han-Chinese individuals from Luzhou area. There was no substantial linkage disequilibrium (LD) among the 21 autosomal STR markers, and all markers were in Hardy-Weinberg equilibrium (HWE). The total discrimination power (TDP) and cumulative probability of exclusion (CPE) of the 21 autosomal STR loci were calculated to be 1-9.8505 × 10 and 1-1.9406 × 10, respectively. There were 333 alleles for 21 STRs with allelic frequencies ranging from 0.00026 to 0.51302, and the number of alleles ranged from 7 in locus TPOX to 29 in locus Penta E. According to the results of population comparison and population differentiation, historical influences, geographical distribution, cultural integration, and economic development may have an impact on the Luzhou Han population and other Chinese populations. These 21 STR loci were found to enrich autosomal STR information in forensic databases and provide highly informative polymorphisms for our forensic practice in China, including personal identification and parentage testing.
汉族是一个古老而人口众多的民族，中国的不同地区可能有其独特的群体关系。泸州地区作为中国西南地区几个省份的交汇处，缺乏常染色体短串联重复序列（STR）研究和群体遗传学研究。本研究评估了来自泸州地区的 1959 名汉族个体的 21 个常染色体 STR 基因座。21 个常染色体 STR 标记之间没有明显的连锁不平衡（LD），所有标记均处于哈迪-温伯格平衡（HWE）状态。21 个常染色体 STR 基因座的总判别力（TDP）和累计排除概率（CPE）分别计算为 1-9.8505×10 和 1-1.9406×10。21 个 STR 基因座有 333 个等位基因，等位基因频率范围为 0.00026-0.51302，等位基因数范围为 7-29。根据群体比较和群体分化的结果，历史影响、地理分布、文化融合和经济发展可能对泸州汉族人口和其他中国人口产生影响。这 21 个 STR 基因座丰富了法医学数据库中的常染色体 STR 信息，为中国的法医学实践提供了高度信息多态性，包括个人识别和亲子鉴定。
