不成熟血小板分数可作为儿童 2019 年呼吸道冠状病毒疾病严重程度的生物标志物。
Immature Platelet Fraction as a Biomarker for Disease Severity in Pediatric Respiratory Coronavirus Disease 2019.
机构信息
Departments of Internal Medicine and Pediatrics, University of Texas Southwestern, Dallas, TX.
School of Data Science, University of North Carolina at Charlotte, Charlotte, NC.
出版信息
J Pediatr. 2022 Dec;251:187-189. doi: 10.1016/j.jpeds.2022.07.035. Epub 2022 Aug 6.
Abstract
In this retrospective single-institution cohort study of 113 hospitalized pediatric patients with respiratory coronavirus disease 2019, those admitted to the intensive care unit or requiring mechanical ventilation had significantly higher immature platelet fractions than those who did not require intensive care unit-level care or ventilation. Immature platelet fraction may be an accessible biomarker for disease severity in pediatric respiratory coronavirus disease 2019.
摘要
在这项回顾性单机构队列研究中，纳入了 113 例住院的儿科 2019 冠状病毒病患者，与不需要重症监护或通气的患者相比，需要入住重症监护病房或需要机械通气的患者血小板未成熟分数明显更高。血小板未成熟分数可能是儿科 2019 冠状病毒病严重程度的一种易于获取的生物标志物。
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本文引用的文献
1
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Br J Haematol. 2021 Aug;194(3):494-495. doi: 10.1111/bjh.17676. Epub 2021 Jul 11.
2
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3
Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Lancet. 2021 May 1;397(10285):1637-1645. doi: 10.1016/S0140-6736(21)00676-0.
4
Biomarkers in COVID-19: An Up-To-Date Review.
Front Pediatr. 2021 Mar 30;8:607647. doi: 10.3389/fped.2020.607647. eCollection 2020.
5
Severe Acute Respiratory Syndrome Coronavirus 2 Clinical Syndromes and Predictors of Disease Severity in Hospitalized Children and Youth.
J Pediatr. 2021 Mar;230:23-31.e10. doi: 10.1016/j.jpeds.2020.11.016. Epub 2020 Nov 14.
6
Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study.
BMJ. 2020 Aug 27;370:m3249. doi: 10.1136/bmj.m3249.
7
IL-6-based mortality risk model for hospitalized patients with COVID-19.
J Allergy Clin Immunol. 2020 Oct;146(4):799-807.e9. doi: 10.1016/j.jaci.2020.07.009. Epub 2020 Jul 22.
8
Association of immature platelets with adverse cardiovascular outcomes.
J Am Coll Cardiol. 2014;64(20):2122-9. doi: 10.1016/j.jacc.2014.06.1210. Epub 2014 Nov 10.
9
Active thrombopoiesis is associated with worse severity and activity of chronic GVHD.
Bone Marrow Transplant. 2013 Nov;48(12):1569-73. doi: 10.1038/bmt.2013.95. Epub 2013 Jul 8.
10
Immature platelet fraction in predicting sepsis in critically ill patients.
Intensive Care Med. 2013 Apr;39(4):636-43. doi: 10.1007/s00134-012-2725-7. Epub 2012 Oct 24.
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