由鼠单克隆抗体定义的犬淋巴瘤相关抗原。
Canine lymphoma-associated antigens defined by murine monoclonal antibodies.
作者信息
Steplewski Z, Jeglum K A, Rosales C, Weintraub N
出版信息
Cancer Immunol Immunother. 1987;24(3):197-201. doi: 10.1007/BF00205629.
Abstract
Lymphoma in dogs resembles human non-Hodgkin's lymphoma in pathological presentation, immunophenotype, and response to therapy, thus representing a good model for comparative studies with human disease. Monoclonal antibodies (MAbs) were derived from mice immunized with a dog lymphoma cell line. Three MAbs were selected for further application in immunophenotyping and immunotherapy. The binding specificities, antigen characterization, and isotypes for these MAbs are described.
摘要
犬淋巴瘤在病理表现、免疫表型及对治疗的反应方面与人类非霍奇金淋巴瘤相似，因此是用于与人类疾病进行比较研究的良好模型。单克隆抗体（MAb）源自用犬淋巴瘤细胞系免疫的小鼠。选择了三种单克隆抗体用于免疫表型分析和免疫治疗的进一步应用。描述了这些单克隆抗体的结合特异性、抗原特性和免疫球蛋白类型。
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