Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Ahmedabad, Opposite Air Force Station, Palaj, Gandhinagar, Gujarat, 382355, India.
Cell Mol Neurobiol. 2023 May;43(4):1519-1535. doi: 10.1007/s10571-022-01266-9. Epub 2022 Aug 9.
Endothelial cells (ECs) and pericytes are present in all blood vessels. Their position confers an important role in controlling oxygen and nutrient transportation to the different organs. ECs can adopt different morphologies based on their need and functions. Both ECs and pericytes express different surface markers that help in their identification, but heterogeneity and overlapping between markers among different cells pose a challenge for their precise identification. Spatiotemporal association of ECs and pericytes have great importance in sprout formation and vessel stabilization. Any traumatic injury in CNS may lead to vascular damage along with neuronal damage. Hence, ECs-pericyte interaction by physical contact and paracrine molecules is crucial in recovering the epicenter region by promoting angiogenesis. ECs can transform into other types of cells through endothelial-mesenchymal transition (EndMT), promoting wound healing in the epicenter region. Various signaling pathways mediate the interaction of ECs with pericytes that have an extensive role in angiogenesis. In this review, we discussed ECs and pericytes surface markers, the spatiotemporal association and interaction of ECs-pericytes, and signaling associated with the pathology of traumatic SCI. Linking the brain or spinal cord-specific pathologies and human vascular pathology will pave the way toward identifying new therapeutic targets and developing innovative preventive strategies. Endothelial-pericyte interaction strategic for formation of functional neo-vessels that are crucial for neurological recovery.
内皮细胞 (ECs) 和周细胞存在于所有血管中。它们的位置在控制氧气和营养物质向不同器官的运输中起着重要作用。ECs 可以根据需要和功能采用不同的形态。ECs 和周细胞都表达不同的表面标志物，有助于对其进行识别，但不同细胞之间标志物的异质性和重叠性给其精确识别带来了挑战。ECs 和周细胞的时空关联在芽生和血管稳定中具有重要意义。中枢神经系统的任何创伤性损伤都可能导致血管损伤和神经元损伤。因此，通过物理接触和旁分泌分子的 ECs-周细胞相互作用对于通过促进血管生成来恢复中心区域至关重要。ECs 可以通过内皮间充质转化 (EndMT) 转化为其他类型的细胞，从而促进中心区域的伤口愈合。各种信号通路介导 ECs 与周细胞的相互作用，在血管生成中起着广泛的作用。在这篇综述中，我们讨论了 ECs 和周细胞的表面标志物、ECs-周细胞的时空关联和相互作用，以及与创伤性 SCI 病理相关的信号。将大脑或脊髓特定的病理与人类血管病理联系起来，将为确定新的治疗靶点和开发创新的预防策略铺平道路。内皮-周细胞相互作用对于功能性新血管的形成至关重要，这对于神经恢复至关重要。
