小鼠致命性和自限性疟疾感染过程中的脾细胞变化。
Spleen cell changes during fatal and self-limiting malarial infections of mice.
作者信息
Freeman R R, Parish C R
出版信息
Immunology. 1978 Sep;35(3):479-84.
Changes in the proportions and total numbers of splenic Thy-1.2+ cells, Ig+ cells and normoblasts were analysed during fatal Plasmodium berghei and non-fatal P. yoelii infections in mice. Thy-1.2+ and Ig+ cells were identified by rosetting techniques, and normoblasts by morphological criteria. The splenomegaly observed during these infections was found to be caused mainly by proliferation of normoblasts. An early increase in the numbers of Thy-1.2+ and Ig+ cells was detected in both infections, but in P. berghei infections these responses were subsequently suppressed. In P. yoelii infections Thy-1.2+ and Ig+ cell numbers were maintained at four to five-fold above normal levels until the mice had completely recovered. During the acute phase of P. yoelii infection it appeared that most splenic T-cells expressed surface immunoglobulin.
在小鼠感染致死性伯氏疟原虫和非致死性约氏疟原虫的过程中，分析了脾脏中Thy-1.2⁺细胞、Ig⁺细胞和成红细胞的比例及总数的变化。Thy-1.2⁺和Ig⁺细胞通过玫瑰花结技术鉴定，成红细胞通过形态学标准鉴定。发现在这些感染过程中观察到的脾肿大主要是由成红细胞增殖引起的。在两种感染中均检测到Thy-1.2⁺和Ig⁺细胞数量早期增加，但在伯氏疟原虫感染中，这些反应随后受到抑制。在约氏疟原虫感染中，Thy-1.2⁺和Ig⁺细胞数量维持在高于正常水平四到五倍，直至小鼠完全恢复。在约氏疟原虫感染的急性期，似乎大多数脾脏T细胞表达表面免疫球蛋白。
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