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小鼠淋巴细胞的玫瑰花结形成。III. 正常和活化T细胞上免疫球蛋白的受体

Rosette formation by mouse lymphocytes. III. Receptors for immunoglobulin on normal and activated T cells.

作者信息

Soteriades-Vlachos C, Gyöngyössy M I, Playfair J H

出版信息

Clin Exp Immunol. 1974 Oct;18(2):187-92.

Abstract

By the use of an indirect immunofluorescent method for the identification of mouse T lymphocytes forming rosettes with antibody-coated erythrocytes, it was found that about 10% of the T cells in normal mouse spleen have receptors for antibody. Inhibition experiments with purified aggregated immunoglobulins showed that IgG2 is the major class involved. The same receptor was found on T cells activated against H-2 isoantigens. The importance of using the appropriate red cells and antiserum for demonstrating receptors on T cells is stressed.

摘要

通过使用间接免疫荧光法鉴定与抗体包被红细胞形成玫瑰花结的小鼠T淋巴细胞,发现正常小鼠脾脏中约10%的T细胞具有抗体受体。用纯化的聚合免疫球蛋白进行的抑制实验表明,IgG2是主要涉及的类别。在针对H-2同种异型抗原活化的T细胞上也发现了相同的受体。强调了使用合适的红细胞和抗血清来证明T细胞上的受体的重要性。

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Monospecificity of bone marrow-derived lymphocytes.骨髓来源淋巴细胞的单特异性
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