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小鼠淋巴细胞的玫瑰花结形成。III. 正常和活化T细胞上免疫球蛋白的受体

Rosette formation by mouse lymphocytes. III. Receptors for immunoglobulin on normal and activated T cells.

作者信息

Soteriades-Vlachos C, Gyöngyössy M I, Playfair J H

出版信息

Clin Exp Immunol. 1974 Oct;18(2):187-92.

PMID:4549625
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1537899/
Abstract

By the use of an indirect immunofluorescent method for the identification of mouse T lymphocytes forming rosettes with antibody-coated erythrocytes, it was found that about 10% of the T cells in normal mouse spleen have receptors for antibody. Inhibition experiments with purified aggregated immunoglobulins showed that IgG2 is the major class involved. The same receptor was found on T cells activated against H-2 isoantigens. The importance of using the appropriate red cells and antiserum for demonstrating receptors on T cells is stressed.

摘要

通过使用间接免疫荧光法鉴定与抗体包被红细胞形成玫瑰花结的小鼠T淋巴细胞，发现正常小鼠脾脏中约10%的T细胞具有抗体受体。用纯化的聚合免疫球蛋白进行的抑制实验表明，IgG2是主要涉及的类别。在针对H-2同种异型抗原活化的T细胞上也发现了相同的受体。强调了使用合适的红细胞和抗血清来证明T细胞上的受体的重要性。

相似文献

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Rosette formation by mouse lymphocytes. III. Receptors for immunoglobulin on normal and activated T cells.小鼠淋巴细胞的玫瑰花结形成。III. 正常和活化T细胞上免疫球蛋白的受体
Clin Exp Immunol. 1974 Oct;18(2):187-92.
2
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Rosette formation by mouse lymphocytes. I. Demonstration by indirect immunofluorescence of T cells binding sheep erythrocytes.小鼠淋巴细胞的玫瑰花结形成。I. 通过间接免疫荧光法证明T细胞与绵羊红细胞的结合。
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[Development of concepts concerning autoimmunity and tolerance to the body's own antigens].
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引用本文的文献

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Evidence for antibody-dependent cell-mediated cytotoxicity by T cells bearing receptors for IgG.带有IgG受体的T细胞介导的抗体依赖性细胞毒性的证据。
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本文引用的文献

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Ca++-dependent binding of antigen-19 S antibody complexes to macrophages.抗原-19S抗体复合物与巨噬细胞的钙离子依赖性结合。
J Immunol. 1969 May;102(5):1172-8.
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The morphology of immune reactions in normal, thymectomized and reconstituted mice. II. The response to oxazolone.正常、胸腺切除及重建小鼠免疫反应的形态学。II. 对恶唑酮的反应。
Immunology. 1969 Jul;17(1):111-26.
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The detection and production of macrophage cytophilic antibody to different antigens in different laboratory animals.不同实验动物中针对不同抗原的巨噬细胞嗜细胞抗体的检测与产生
Immunology. 1971 Dec;21(6):1045-58.
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A receptor for antibody on B lymphocytes. II. Immunochemical and electron microscopy characteristics.B淋巴细胞上的抗体受体。II. 免疫化学和电子显微镜特征
J Exp Med. 1972 Mar 1;135(3):627-42. doi: 10.1084/jem.135.3.627.
5
A receptor for antibody on B lymphocytes. I. Method of detection and functional significance.B淋巴细胞上的抗体受体。I. 检测方法及功能意义。
J Exp Med. 1972 Mar 1;135(3):610-26. doi: 10.1084/jem.135.3.610.
6
Characterization of the antibody-dependent cytotoxic cell. A non-phagocytic monocyte?抗体依赖性细胞毒性细胞的特性。一种非吞噬性单核细胞？
Clin Exp Immunol. 1973 Oct;15(2):251-9.
7
Reaginic antibodies on basophils in grass pollen allergy, as shown by rosette-formation.如玫瑰花结形成所示，草花粉过敏患者嗜碱性粒细胞上的反应素抗体。
Int Arch Allergy Appl Immunol. 1972;42(5):668-80. doi: 10.1159/000230647.
8
The binding of human IgG subclasses to human monocytes.人免疫球蛋白G亚类与人单核细胞的结合。
Eur J Immunol. 1972 Jun;2(3):257-61. doi: 10.1002/eji.1830020312.
9
Indirect immunofluorescence of mouse thymus-derived cells using heterologous anti-brain serum.使用异种抗脑血清对小鼠胸腺来源细胞进行间接免疫荧光检测。
Cell Immunol. 1973 Apr;7(1):118-23. doi: 10.1016/0008-8749(73)90187-1.
10
Monospecificity of bone marrow-derived lymphocytes.骨髓来源淋巴细胞的单特异性
J Exp Med. 1973 Apr 1;137(4):1024-30. doi: 10.1084/jem.137.4.1024.