de Souza J B, Playfair J H
Clin Exp Immunol. 1983 Oct;54(1):110-6.
The anti-lymphocyte autoantibody response to irradiated lethal Plasmodium berghei malaria parasites in normal mice was significantly reduced when recipients were pre-treated with splenic T cells from mice recovered from a non-lethal Plasmodium yoelii infection. Suppression was specific for the autoantibody and did not affect the antibody response to the parasite. Experiments involving sequential P. yoelii-P. berghei infections in situ revealed that recovery from P. berghei was possible when the interval between the two infections was 14 days or more. This ability to recover from P. berghei correlated with a progressive reduction of anti-lymphocyte autoantibody suggesting a useful role for the suppressor cell. The possible link between suppressor cells and anti-lymphocyte autoantibodies in malaria is discussed.
当受体小鼠预先接受来自从非致死性约氏疟原虫感染中恢复的小鼠的脾T细胞处理后，正常小鼠对经辐照的致死性伯氏疟原虫疟原虫的抗淋巴细胞自身抗体反应显著降低。抑制作用对自身抗体具有特异性，并不影响对寄生虫的抗体反应。涉及原位序贯约氏疟原虫-伯氏疟原虫感染的实验表明，当两次感染之间的间隔为14天或更长时间时，从伯氏疟原虫感染中恢复是可能的。从伯氏疟原虫感染中恢复的这种能力与抗淋巴细胞自身抗体的逐渐减少相关，提示抑制细胞具有有益作用。文中讨论了疟疾中抑制细胞与抗淋巴细胞自身抗体之间的可能联系。
