盐酸米诺环素含漱液治疗复发性阿弗他溃疡的临床疗效：一项随机对照试验。
The clinical efficacy of minocycline mouth rinse on recurrent aphthous stomatitis-A randomized controlled trial.
机构信息
Department of Dentistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
出版信息
Indian J Dent Res. 2022 Jan-Mar;33(1):24-29. doi: 10.4103/ijdr.IJDR_478_20.
INTRODUCTION
Recurrent aphthous stomatitis (RAS) is one of the most common ulcerative diseases affecting the general population. The present study aimed to evaluate the clinical efficiency of 0.5% minocycline mouth rinse prescribed along with the topical anesthetic gel and vitamin supplement over the topical anesthetic gel and vitamin supplement prescribed alone for treating RAS.
MATERIALS AND METHODS
A total of 60 participants were randomly divided into two groups-experimental group: 0.5% minocycline mouth rinse prescribed along with vitamin supplement and topical anesthetic gel; and control group: vitamin supplement and topical anesthetic gel alone. The pain symptoms were evaluated using the VAS scores at baseline and first follow-up visits. The data were analyzed using Student's t test.
RESULTS
A significant reduction in the pain scores was observed in participants using the 0.5% minocycline mouth rinse prescribed along with vitamin supplement and topical anesthetic gel on the first follow-up visit (P = < 0.001).
CONCLUSION
The 0.5% minocycline mouth rinse prescribed along with vitamin supplement and topical anesthetic gel had shown more reduction in the pain symptoms when compared to topical anesthetic gel and vitamin supplement prescribed alone for the treatment of RAS.
简介
复发性阿弗他口炎（RAS）是影响普通人群的最常见溃疡病之一。本研究旨在评估 0.5%米诺环素漱口液联合局部麻醉凝胶和维生素补充剂与单独使用局部麻醉凝胶和维生素补充剂治疗 RAS 的临床疗效。
材料和方法
共有 60 名参与者被随机分为两组 - 实验组：0.5%米诺环素漱口液联合维生素补充剂和局部麻醉凝胶；对照组：单独使用维生素补充剂和局部麻醉凝胶。在基线和第一次随访时使用 VAS 评分评估疼痛症状。使用学生 t 检验对数据进行分析。
结果
在第一次随访时，使用 0.5%米诺环素漱口液联合维生素补充剂和局部麻醉凝胶的参与者的疼痛评分显著降低（P<0.001）。
结论
与单独使用局部麻醉凝胶和维生素补充剂相比，0.5%米诺环素漱口液联合维生素补充剂和局部麻醉凝胶在治疗 RAS 时疼痛症状的减轻更为明显。
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