Experimental Imaging Centre, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.
Medical Physics Department, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.
Med Phys. 2022 Oct;49(10):6588-6598. doi: 10.1002/mp.15914. Epub 2022 Aug 24.
To investigate the feasibility of radioluminescence imaging (RLI) as a novel 2D quality assurance (QA) dosimetry system for CyberKnife®.
We developed a field size measurement system based on a commercial complementary metal oxide semiconductor (CMOS) camera facing a radioluminescence screen located at the isocenter normal to the beam axis. The radioluminescence light collected by a lens was used to measure 2D dose distributions. An image transformation procedure, based on two reference phantoms, was developed to correct for projective distortion due to the angle (15°) between the optical and beam axis. Dose profiles were measured for field sizes ranging from 5 mm to 60 mm using fixed circular and iris collimators and compared against gafchromic (GC) film. The corresponding full width at half maximum (FWHM) was measured using RLI and benchmarked against GC film. A small shift in the source-to-surface distance (SSD) of the measurement plane was intentionally introduced to test the sensitivity of the RLI system to field size variations. To assess reproducibility, the entire RLI procedure was tested by acquiring the 60 mm circle field three times on two consecutive days.
The implemented procedure for perspective image distortion correction showed improvements of up to 1 mm using the star phantom against the square phantom. The FWHM measurements using the RLI system indicated a strong agreement with GC film with maximum absolute difference equal to 0.131 mm for fixed collimators and 0.056 mm for the iris. A 2D analysis of RLI with respect to GC film showed that the differences in the central region are negligible, while small discrepancies are in the penumbra region. Changes in field sizes of 0.2 mm were detectable by RLI. Repeatability measurements of the beam FWHM have shown a standard deviation equal to 0.11 mm.
The first application of a RLI approach for CyberKnife® field size measurement was presented and tested. Results are in agreement with GC film measurements. Spatial resolution and immediate availability of the data indicate that RLI is a feasible technique for robotic radiosurgery QA.
研究放射发光成像(RLI)作为一种新型的 CyberKnife®二维质量保证(QA)剂量测定系统的可行性。
我们开发了一种基于商业互补金属氧化物半导体(CMOS)相机的射野大小测量系统,该相机面向位于光束轴垂直的等中心处的放射发光屏幕。透镜收集的放射发光光用于测量二维剂量分布。开发了一种图像变换程序,基于两个参考体模,用于校正由于光学轴和光束轴之间的角度(15°)引起的投影失真。使用固定的圆形和虹膜准直器测量了 5 毫米至 60 毫米的射野大小,并与 Gafchromic(GC)胶片进行了比较。使用 RLI 测量了相应的半高全宽(FWHM),并与 GC 胶片进行了基准测试。有意引入测量平面源皮距(SSD)的小偏移,以测试 RLI 系统对射野大小变化的灵敏度。为了评估重现性,在两天内连续三次获取 60 毫米圆形射野,测试了整个 RLI 过程。
实施的透视图像失真校正程序使用星体模相对于方体模显示出高达 1 毫米的改进。使用 RLI 系统进行的 FWHM 测量与 GC 胶片具有很强的一致性,最大绝对差值为固定准直器的 0.131 毫米和虹膜的 0.056 毫米。与 GC 胶片相比,RLI 的二维分析表明,中心区域的差异可以忽略不计,而在半影区域存在小的差异。通过 RLI 可以检测到 0.2 毫米的射野大小变化。光束 FWHM 的重复性测量显示标准偏差等于 0.11 毫米。
首次提出并测试了 RLI 方法在 CyberKnife®射野大小测量中的应用。结果与 GC 胶片测量结果一致。空间分辨率和数据的即时可用性表明,RLI 是机器人放射外科 QA 的一种可行技术。