Pontifícia Universidade Católica do Rio de Janeiro, Departamento de Psicologia, Rio de Janeiro RJ, Brazil.
Università degli Studi di Perugia, Dipartimento di Filosofia, scienze sociali, umane e della formazione, Perugia, Italia.
Arq Neuropsiquiatr. 2022 Jun;80(6):570-579. doi: 10.1590/0004-282X-ANP-2021-0099.
Reaction time is affected under different neurological conditions but has not been much investigated considering all types of mild cognitive impairment (MCI).
This study investigated the diagnostic accuracy of CompCog, a computerized cognitive screening battery focusing on reaction time measurements.
A sample of 52 older adults underwent neuropsychological assessments, including CompCog, and medical appointments, to be classified as a control group or be diagnosed with MCI. The accuracy of CompCog for distinguishing between the two groups was calculated.
The results from diagnostic accuracy analyses showed that the AUCs of ROC curves were as high as 0.915 (CI 0.837-0.993). The subtest with the highest sensitivity and specificity (choice reaction time subtest) had 91.7% sensitivity and 89.3% specificity. The logistic regression final model correctly classified 92.3% of individuals, with 92.9% specificity and 91.7% sensitivity, and included only four variables from different subtests.
In summary, the study showed that reaction time assessed through CompCog is a good screening measure to differentiate between normal aging and MCI. Reaction time measurements in milliseconds were more accurate than correct answers. This test can form part of routine clinical tests to achieve the objectives of screening for MCI, indicating further procedures for investigation and diagnosis and planning interventions.
反应时间会受到不同神经状态的影响，但考虑到所有类型的轻度认知障碍（MCI），其并未得到太多研究。
本研究调查了 CompCog 的诊断准确性，CompCog 是一种专注于反应时间测量的计算机化认知筛查工具。
一组 52 名老年人接受了神经心理学评估，包括 CompCog 和医疗预约，以被分类为对照组或被诊断为 MCI。计算 CompCog 区分两组的准确性。
诊断准确性分析的结果显示，ROC 曲线的 AUC 高达 0.915（CI 0.837-0.993）。灵敏度和特异性最高的亚测试（选择反应时亚测试）的灵敏度为 91.7%，特异性为 89.3%。逻辑回归最终模型正确分类了 92.3%的个体，特异性为 92.9%，灵敏度为 91.7%，仅包含来自不同亚测试的四个变量。
综上所述，该研究表明，通过 CompCog 评估的反应时间是区分正常衰老和 MCI 的良好筛查措施。以毫秒为单位的反应时间测量比正确答案更准确。该测试可以作为常规临床测试的一部分，以实现 MCI 的筛查目标，指示进一步的调查和诊断程序以及干预计划。
