用于胃癌早期诊断的新型生物标志物：胃液和血清来源的 SNCG。
A new biomarker for the early diagnosis of gastric cancer: gastric juice- and serum-derived SNCG.
机构信息
Precision Clinical Laboratory, Central People's Hospital of Zhanjiang, Zhanjiang, Guangdong, China.
Key Laboratory of Xinjiang Endemic & Ethnic Disease, School of Medicine, Shihezi University, Shihezi, Xinjiang, China.
出版信息
Future Oncol. 2022 Sep;18(28):3179-3190. doi: 10.2217/fon-2022-0253. Epub 2022 Aug 10.
To explore the possibility of gastric juice (GJ)- and serum-derived SNCG as a potential biomarker for the early diagnosis of gastric cancer (GC). GJ and serum samples were collected from 87 patients with GC, 38 patients with gastric precancerous lesions and 44 healthy volunteers. The levels of SNCG in GJ and serum samples were detected by ELISA. The levels of SNCG in GJ and serum were significantly higher in the GC group when compared with the GPL group or the control group. The expression of SNCG in GJ and serum was associated with tumor node metastasis stage, lymph node metastasis, tumor size and drinking, and it is important for the diagnosis and prognosis of GC (p < 0.05). The findings highlight the significance of SNCG in GC diagnosis and prognosis and implicate SNCG as a promising candidate for GC treatment.
目的
探索胃液（GJ）和血清来源的 SNCG 作为胃癌（GC）早期诊断潜在生物标志物的可能性。 收集 87 例 GC 患者、38 例胃癌前病变患者和 44 例健康志愿者的 GJ 和血清样本。通过 ELISA 检测 GJ 和血清样本中 SNCG 的水平。GC 组 GJ 和血清中的 SNCG 水平明显高于 GPL 组或对照组。GJ 和血清中 SNCG 的表达与肿瘤淋巴结转移分期、淋巴结转移、肿瘤大小和饮酒有关，对 GC 的诊断和预后具有重要意义（p < 0.05）。 这些发现强调了 SNCG 在 GC 诊断和预后中的重要性，并暗示 SNCG 是 GC 治疗的有前途的候选物。
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