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总乳制品、高脂肪乳制品和低脂肪乳制品摄入量与抑郁症状之间的关联:基于人群的横断面研究结果。

Associations between total dairy, high-fat dairy and low-fat dairy intake, and depressive symptoms: findings from a population-based cross-sectional study.

机构信息

IMPACT (The Institute for Mental and Physical Health and Clinical Translation), Food & Mood Centre, Deakin University, Geelong, Australia.

Faculty of Health, Biostatistics Unit, Deakin University, Geelong, Australia.

出版信息

Eur J Nutr. 2023 Feb;62(1):227-237. doi: 10.1007/s00394-022-02950-8. Epub 2022 Aug 10.

Abstract

PURPOSE

Evidence on the association between dairy intake and depression is conflicting. Given numerous dietary guidelines recommend the consumption of low-fat dairy products, this study examined associations between total dairy, high-fat dairy, and low-fat dairy intake and the prevalence of elevated depressive symptoms. Associations between dairy products, which differed in both fat content and fermentation status, and depressive symptoms were also explored.

METHODS

This cross-sectional study included 1600 Finnish adults (mean age 63 ± 6 years; 51% female) recruited as part of the Kuopio Ischaemic Heart Disease Risk Factor Study. Dairy intake was assessed using 4-day food records. Elevated depressive symptoms were defined as having a score ≥ 5 on the Diagnostic and Statistical Manual of Mental Disorders-III Depression Scale, and/or regularly using one or more prescription drugs for depressive symptoms.

RESULTS

In total, 166 participants (10.4%) reported having elevated depressive symptoms. Using multivariate logistic regression models, intake in the highest tertile of high-fat dairy products (OR 0.64, 95% CI 0.41-0.998, p trend = 0.04) and high-fat non-fermented dairy products (OR 0.60, 95% CI 0.39-0.92, p trend = 0.02) were associated with reduced odds for having elevated depressive symptoms. Whereas no significant association was observed between intake of total dairy, low-fat dairy, or other dairy products, and depressive symptoms.

CONCLUSION

Higher intake of high-fat dairy and high-fat non-fermented dairy products were associated with reduced odds for having elevated depressive symptoms in middle-aged and older Finnish adults. Given the high global consumption of dairy products, and widespread burden of depression, longitudinal studies that seek to corroborate these findings are required.

摘要

目的

关于乳制品摄入与抑郁之间的关联,证据相互矛盾。鉴于许多饮食指南建议食用低脂乳制品,本研究调查了总乳制品、高脂肪乳制品和低脂乳制品摄入与抑郁症状升高的患病率之间的关联。还探讨了乳制品之间的关联,这些乳制品在脂肪含量和发酵状态上有所不同,以及与抑郁症状的关联。

方法

这项横断面研究包括 1600 名芬兰成年人(平均年龄 63±6 岁;51%为女性),作为库奥皮奥缺血性心脏病风险因素研究的一部分被招募。乳制品摄入量通过 4 天的食物记录来评估。抑郁症状升高的定义为使用诊断和统计手册-III 精神障碍抑郁量表的评分≥5,和/或定期使用一种或多种治疗抑郁症状的处方药。

结果

共有 166 名参与者(10.4%)报告有抑郁症状升高。使用多变量逻辑回归模型,高脂肪乳制品摄入量最高三分位组(OR 0.64,95%CI 0.41-0.998,p 趋势=0.04)和高脂肪非发酵乳制品(OR 0.60,95%CI 0.39-0.92,p 趋势=0.02)与抑郁症状升高的几率降低相关。而总乳制品、低脂乳制品或其他乳制品的摄入量与抑郁症状之间没有显著关联。

结论

在中年和老年芬兰成年人中,较高的高脂肪乳制品和高脂肪非发酵乳制品摄入量与抑郁症状升高的几率降低相关。鉴于全球乳制品的高消耗量以及普遍存在的抑郁负担,需要进行旨在证实这些发现的纵向研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b42f/9899713/18d5e22d9ab7/394_2022_2950_Fig1_HTML.jpg

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