Department of Transfusion, The Affiliated Hospital of Southwest Medical University, 25 Taiping Road, Luzhou, 646000, Sichuan, People's Republic of China.
Department of Clinical Medicine, Southwest Medical University, Luzhou, 646000, China.
Clin Transl Oncol. 2022 Dec;24(12):2285-2294. doi: 10.1007/s12094-022-02906-8. Epub 2022 Aug 10.
Liver cancer is a disease with high morbidity and mortality. More and more studies have shown that exosomes can be used as biomarkers for the diagnosis of liver cancer, but their diagnostic accuracy is still unclear. Therefore, this meta-analysis summarizes various studies on the diagnostic value of exosomes for liver cancer.
A comprehensive search was carried out based on the set search terms in PubMed, Web of Science and Wiley until April 1, 2022. All statistical analyses were performed by STATA 17 statistical software and Review Manager 5.4. Quality Assessment for Studies of Diagnostic Accuracy 2 tool was applied to evaluate the quality of included articles. Random effects model was used to calculate various diagnostic indicators.
A total of 47 studies were included in this meta-analysis. The number of participants was 3196. The combined sensitivity, specificity and the area under the curve with 95% confidence intervals (95% CI) were, respectively 0.80 (0.75-0.84), 0.83 (0.79-0.87), 0.89 (0.85-0.91).
This meta-analysis shows that exosomes have good diagnostic accuracy for liver cancer and can be used as an effective biomarker for the diagnosis of liver cancer.
肝癌是一种发病率和死亡率都很高的疾病。越来越多的研究表明，外泌体可以作为肝癌诊断的生物标志物，但它们的诊断准确性仍不清楚。因此，这项荟萃分析总结了各种关于外泌体诊断肝癌价值的研究。
根据设定的搜索词，在 PubMed、Web of Science 和 Wiley 中进行全面搜索，截至 2022 年 4 月 1 日。所有的统计分析均由 STATA 17 统计软件和 Review Manager 5.4 进行。采用诊断准确性研究质量评估工具 2 来评价纳入文章的质量。使用随机效应模型计算各种诊断指标。
这项荟萃分析共纳入 47 项研究，共 3196 名参与者。合并敏感度、特异度和 95%置信区间（95%CI）下的曲线下面积分别为 0.80（0.75-0.84）、0.83（0.79-0.87）、0.89（0.85-0.91）。
这项荟萃分析表明，外泌体对肝癌具有良好的诊断准确性，可以作为肝癌诊断的有效生物标志物。
