Department of General Surgery, First Affiliated Hospital of Anhui Medical University, Anhui, Hefei, 230022, China.
Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Anhui, Hefei, 230032, China.
Mol Med. 2023 May 22;29(1):66. doi: 10.1186/s10020-023-00665-y.
Cancer-associated fibroblasts (CAFs) are the most abundant stromal cells within the tumor microenvironment (TME). They extensively communicate with the other cells. Exosome-packed bioactive molecules derived from CAFs can reshape the TME by interacting with other cells and the extracellular matrix, which adds a new perspective for their clinical application in tumor targeted therapy. An in-depth understanding of the biological characteristics of CAF-derived exosomes (CDEs) is critical for depicting the detailed landscape of the TME and developing tailored therapeutic strategies for cancer treatment. In this review, we have summarized the functional roles of CAFs in the TME, particularly focusing on the extensive communication mediated by CDEs that contain biological molecules such as miRNAs, proteins, metabolites, and other components. In addition, we have also highlighted the prospects for diagnostic and therapeutic applications based on CDEs, which could guide the future development of exosome-targeted anti-tumor drugs.
癌相关成纤维细胞（CAFs）是肿瘤微环境（TME）中最丰富的基质细胞。它们与其他细胞广泛交流。来自 CAFs 的含有外泌体的生物活性分子可以通过与其他细胞和细胞外基质相互作用来重塑 TME，这为其在肿瘤靶向治疗中的临床应用增添了新的视角。深入了解 CAF 衍生的外泌体（CDE）的生物学特性对于描绘 TME 的详细景观和开发针对癌症治疗的定制治疗策略至关重要。在这篇综述中，我们总结了 CAFs 在 TME 中的功能作用，特别关注了由包含 miRNA、蛋白质、代谢物和其他成分等生物分子的 CDEs 介导的广泛交流。此外，我们还强调了基于 CDE 的诊断和治疗应用的前景，这可以为外泌体靶向抗肿瘤药物的未来发展提供指导。
