基底细胞腺瘤和基底细胞腺癌：单一机构 50 年经验。
Basal Cell Adenoma and Basal Cell Adenocarcinoma: a 50-year Experience From a Single Institution.
机构信息
Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa, R. Prof. Lima Basto, 1099-023, Lisbon, Portugal.
Faculdade de Medicina, Instituto de Anatomia Patológica, Universidade de Lisboa, Lisbon, Portugal.
出版信息
Head Neck Pathol. 2022 Dec;16(4):1157-1166. doi: 10.1007/s12105-022-01484-z. Epub 2022 Aug 10.
BACKGROUND
Basal cell adenoma (BCA) and adenocarcinoma (BCAd) are two of the least frequent salivary gland tumors. We describe the largest series of these neoplasms, spanning over a period of 50 years (1970-2020), diagnosed and treated in a single Institution.
METHODS
Sixty-eight cases were identified. Clinical and pathological data were collected and correlated with outcome.
RESULTS
Forty-one BCA and 27 BCAd were identified. BCA cases had almost pristine prognosis, with only a relapse in a tumor inadequately excised. Ten patients with BCAd developed metastases, and 14 died from the disease. The 2-year and 5-year survival was of 76% and 42%.
CONCLUSIONS
The importance of adequate excision is reinforced in BCA, with no recurrences occurring when margins were negative. Contrary to previous reports, BCAd was not associated with a good prognosis. A better understanding of the genetics of these neoplasms may identify therapeutic options when dealing with inoperable or metastatic disease.
背景
基底细胞腺瘤（BCA）和腺癌（BCAd）是两种最不常见的唾液腺肿瘤。我们描述了在单一机构诊断和治疗的、跨越 50 年（1970-2020 年）的这些肿瘤的最大系列。
方法
鉴定了 68 例。收集了临床和病理数据，并与结果相关联。
结果
确定了 41 例 BCA 和 27 例 BCAd。BCA 病例的预后几乎完美，只有在切除不充分的肿瘤中才会复发。10 例 BCAd 患者发生转移，14 例患者死于该疾病。2 年和 5 年的生存率分别为 76%和 42%。
结论
在 BCA 中，充分切除的重要性得到了加强，当切缘为阴性时，不会发生复发。与之前的报告相反，BCAd 与良好的预后无关。更好地了解这些肿瘤的遗传学可能会为处理不可手术或转移性疾病提供治疗选择。
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