Mor-Avi V, Shargorodsky B, Abboud S, Laniado S, Akselrod S
Circulation. 1987 Jul;76(1):237-43. doi: 10.1161/01.cir.76.1.237.
The very high-frequency content (150 to 250 Hz) of epicardial electrogram waveforms was studied in 19 anesthetized dogs subjected to occlusion of left anterior descending coronary artery. Computer techniques of digital averaging and digital band-pass filtering were applied. Signals were obtained from epicardial electrodes placed in the ischemic left ventricular region and on the noninjured right ventricular surface, and from the body surface electrocardiogram. All recordings were made simultaneously before, during, and after coronary occlusion and subjected to the same analysis. The waveforms obtained from the ischemic left ventricular region showed a considerable decrease in high-frequency content, while those obtained from the noninjured right ventricular surface remained unchanged. The results correlated with the appearance of a zone of reduced amplitude in the body surface high-frequency QRS complex. Therefore, this macroscopic phenomenon measured noninvasively from the body surface is explained by local reduction of high-frequency activity in the ischemic region of the myocardium.
在19只接受左冠状动脉前降支闭塞的麻醉犬中，研究了心外膜电图波形的超高频成分（150至250赫兹）。应用了数字平均和数字带通滤波的计算机技术。信号取自置于缺血左心室区域和未受损右心室表面的心外膜电极，以及体表心电图。所有记录均在冠状动脉闭塞前、闭塞期间和闭塞后同时进行，并进行相同的分析。从缺血左心室区域获得的波形显示高频成分显著减少，而从未受损右心室表面获得的波形保持不变。这些结果与体表高频QRS复合波中振幅降低区域的出现相关。因此，这种从体表无创测量的宏观现象是由心肌缺血区域高频活动的局部降低所解释的。
