Clinic for Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Epidemiology, IQVIA, Frankfurt, Germany.
Ann Palliat Med. 2022 Sep;11(9):2813-2818. doi: 10.21037/apm-22-200. Epub 2022 Aug 10.
Chronic obstructive pulmonary disease (COPD) shares common risk factors with digestive tract malignancies such as esophageal cancer. However, the prevalence and geographic distribution of COPD in patients with gastrointestinal (GI) cancer is only poorly understood.
We used the IQVIA's Oncology Dynamics (OD) database to identify a total of 48,061 patients with GI cancer (4,229 esophagus, 7,568 stomach, 27,300 colon, and 8,964 rectum cancer) from Germany, France, Italy, Spain and the UK.
The prevalence of COPD among the 48,061 patients with GI cancer was 12.5% (5,983/48,061). We observed significant differences in frequencies of COPD between the different cancer sites with the highest COPD prevalence among patients with esophageal (25.5%) or gastric cancer (13.4%) and lowest prevalence in colon (11.0%) or rectal (9.8%) cancer patients. Moreover, rates of COPD strongly varied between digestive tract cancer patients from different countries. Interestingly, Spain (16.8%) and Germany (13.4%) had the highest COPD prevalence while prevalence of COPD was lowest in the UK (8.4%). Finally, we showed that the proportion of digestive tract cancer patients with COPD was highest among male patients (15%) and those >80 years (20.6%) when compared to all other patients.
In this analysis, we show that COPD is found at high frequencies in patients with digestive tract cancer in Europe. We demonstrate that prevalence varies according to digestive tract cancer sites and European countries.
慢性阻塞性肺疾病（COPD）与食管癌等消化道恶性肿瘤有共同的危险因素。然而，胃肠道（GI）癌症患者中 COPD 的患病率和地理分布情况知之甚少。
我们使用 IQVIA 的肿瘤动力学（OD）数据库，从德国、法国、意大利、西班牙和英国共确定了 48061 例 GI 癌症（4229 例食管癌、7568 例胃癌、27300 例结肠癌和 8964 例直肠癌）患者。
48061 例 GI 癌症患者中 COPD 的患病率为 12.5%（5983/48061）。我们观察到不同癌症部位之间 COPD 的患病率存在显著差异，食管癌（25.5%）或胃癌（13.4%）患者的 COPD 患病率最高，结肠癌（11.0%）或直肠癌（9.8%）患者的患病率最低。此外，不同国家的消化道癌患者的 COPD 发生率差异很大。有趣的是，西班牙（16.8%）和德国（13.4%）的 COPD 患病率最高，而英国的 COPD 患病率最低（8.4%）。最后，我们发现与所有其他患者相比，男性患者（15%）和>80 岁的患者（20.6%）中患有 COPD 的消化道癌患者比例最高。
在这项分析中，我们表明 COPD 在欧洲的消化道癌症患者中发病率较高。我们证明了患病率根据消化道癌症部位和欧洲国家而有所不同。
