Bogdanov Vladimir Y, Khirmanov Vladimir N
Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Department of Cardiovascular Medicine, Nikiforov's All-Russian Center for Emergency and Radiation Medicine, Saint Petersburg, Russia.
Vasc Biol. 2022 Jun 8;4(1):R35-R43. doi: 10.1530/VB-22-0004. eCollection 2022 Feb 1.
As we enter year 3 of SARS-CoV-2 pandemic, long-term consequences of COVID-19 have become a major public health issue worldwide; however, the molecular and cellular underpinnings of 'long COVID' remain very poorly understood. A paradigm has recently emerged that thrombo-inflammatory consequences of SARS-CoV-2's impact on endothelial cells and platelets likely play a significant role in the development of chronic symptomatology associated with COVID-19. In this brief overview, we discuss the recent findings pertaining to the detection of SARS-CoV-2 virions in vascular cell subtypes, the contribution of the coagulation system to the development of 'long COVID', and the potential role of stem/progenitor cells in the viral and thrombotic dissemination in this disorder.
随着我们进入新冠病毒大流行的第三年，新冠长期后遗症已成为全球主要的公共卫生问题；然而，“长新冠”的分子和细胞基础仍知之甚少。最近出现了一种模式，即新冠病毒对内皮细胞和血小板的影响所导致的血栓炎症后果可能在与新冠相关的慢性症状发展中起重要作用。在本简要概述中，我们讨论了有关在血管细胞亚型中检测新冠病毒颗粒的最新发现、凝血系统对“长新冠”发展的作用，以及干细胞/祖细胞在该疾病的病毒和血栓传播中的潜在作用。
