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游离皮瓣乳房重建手术患者报告结局的长期研究(PRO-BREST)

Patient-Reported Outcomes in Free-Flap Breast Reconstructive Surgery over Time (PRO-BREST).

作者信息

Fontein Duveken B Y, Oros Melanie, Held Leonhard, Giovanoli Pietro, Pusic Andrea L, Lindenblatt Nicole

机构信息

Department of Plastic Surgery and Hand Surgery, University Hospital Zurich, Zurich, Switzerland.

Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.

出版信息

Breast Care (Basel). 2022 Jun;17(3):272-278. doi: 10.1159/000519804. Epub 2021 Dec 1.

Abstract

INTRODUCTION

Patient-reported outcomes (PROMs) are increasingly relevant to assess surgical quality and guide decisions in breast reconstruction (BR). Satisfaction with outcomes may change as time progresses. We assessed satisfaction in patients who underwent free-flap BR in the last 12 years.

METHODS

All patients who underwent free-flap BR from 2006 to 2018 were invited to complete the validated BREAST-Q for reconstruction. The BREAST-Q comprises 6 domains covering various aspects of satisfaction. Unadjusted linear regression assessed the relationship between different domains of the BREAST-Q and time since BR. Two-sample tests assessed differences in satisfaction between patients who underwent BR ≥5 years versus <5 years prior.

RESULTS

Forty-three women with primary or secondary free-flap BR between 2006 and 2018 were included in the study. Most patients ( = 33, 76.7%) underwent DIEP flap BR. Overall satisfaction with breasts and with outcomes improved as time since BR increased ( = 0.031 and = 0.017, respectively). Overall satisfaction with outcomes scored higher in patients with BR ≥5 years prior (≥5 years vs. <5 years: breast score 88.6 (SD 12.5) versus 66.9 (SD 21.8); = 0.005). Satisfaction with breasts and psychosocial well-being also scored higher in these patients. There was no difference in results between primary and secondary BR. Patients who underwent additional surgery (refinements) reported higher satisfaction with outcomes and abdominal well-being.

CONCLUSIONS

PROMs concerning satisfaction with breast and with outcomes following BR improve as time since treatment progresses. This study demonstrates that time since diagnosis may be an important factor in satisfaction. It underlines the importance of long-term PROMs related to BR, to help provide patients and health care professionals in decision-making and in managing expectations related to BR.

摘要

引言

患者报告结局(PROMs)在评估手术质量和指导乳房重建(BR)决策方面的相关性日益增加。随着时间的推移,对结局的满意度可能会发生变化。我们评估了在过去12年中接受游离皮瓣乳房重建的患者的满意度。

方法

邀请所有在2006年至2018年间接受游离皮瓣乳房重建的患者完成经过验证的BREAST-Q重建问卷。BREAST-Q包括6个领域,涵盖满意度的各个方面。未调整的线性回归评估了BREAST-Q不同领域与乳房重建后时间之间的关系。双样本检验评估了乳房重建≥5年与<5年的患者之间的满意度差异。

结果

本研究纳入了2006年至2018年间进行初次或二次游离皮瓣乳房重建的43名女性。大多数患者(n = 33,76.7%)接受了腹壁下动脉穿支皮瓣乳房重建。随着乳房重建后时间的增加,对乳房和结局的总体满意度有所提高(分别为P = 0.031和P = 0.017)。乳房重建≥5年的患者对结局的总体满意度得分更高(≥5年与<5年相比:乳房得分88.6(标准差12.5)对66.9(标准差21.8);P = 0.005)。这些患者对乳房和心理社会幸福感的满意度也更高。初次和二次乳房重建的结果没有差异。接受额外手术(修复)的患者对结局和腹部幸福感的满意度更高。

结论

随着治疗后时间的推移,与乳房重建后对乳房和结局的满意度相关的患者报告结局有所改善。本研究表明,诊断后的时间可能是影响满意度的一个重要因素。它强调了与乳房重建相关的长期患者报告结局的重要性,以帮助患者和医疗保健专业人员进行决策,并管理与乳房重建相关的期望。

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