Pathology Department, Habib Bourguiba University Hospital, Sfax, Tunisia.
Gynecology and Obstetrics Department, Hedi Chaker University Hospital, Sfax, Tunisia.
Pan Afr Med J. 2022 May 25;42:70. doi: 10.11604/pamj.2022.42.70.31484. eCollection 2022.
Collision tumor is a rare entity composed of two different tumors that occur in close to one another and maintain distinct borders. Only few cases have been reported in the breast. We report the first case of concomitant and adjacent primary angiosarcoma (PBAS) and invasive carcinoma of the breast (IBC), in a 45-year-old patient which presented with a lump in her right breast. Biopsy revealed PBAS. She underwent mastectomy. Gross examination showed a hemorrhagic and spongy tumor in contact with a second small grayish-white mass. Histologically, the hemorrhagic tumor was consistent with a high grade (HG) PBAS; the second mass was consistent with an IBC with no images of histological admixture. The diagnosis of a collision tumor composed of HG PBAS and IBC was established. During follow-up, the patient developed ovarian angiosarcomatous metastasis. The diagnosis of breast collision tumor is very uncommon and hence is challenging for pathologist. Careful gross and microscopic examinations help in establishing the appropriate diagnosis.
碰撞瘤是一种罕见的实体，由两种不同的肿瘤紧密相邻且保持明确边界组成。在乳腺中仅报道了少数病例。我们报告了首例同时发生且相邻的原发性血管肉瘤（PBAS）和乳腺浸润性癌（IBC），患者为 45 岁女性，右侧乳房有肿块。活检显示 PBAS。她接受了乳房切除术。大体检查显示与第二小块灰白色小肿块接触的出血性海绵状肿瘤。组织学上，出血性肿瘤符合高级别（HG）PBAS；第二个肿块符合 IBC，没有组织混合的图像。诊断为 HG PBAS 和 IBC 组成的碰撞瘤。在随访期间，患者发生了卵巢血管肉瘤转移。乳腺碰撞瘤的诊断非常罕见，因此对病理学家来说具有挑战性。仔细的大体和显微镜检查有助于确立适当的诊断。
