Bursa City Hospital, Pulmonary Medicine Clinic, Bursa, Turkey.
Bursa City Hospital Medical Biochemistry, Bursa, Turkey.
Int J Clin Pract. 2022 Aug 3;2022:7450739. doi: 10.1155/2022/7450739. eCollection 2022.
In the early stages of the COVID-19 pandemic, elevated inflammatory cytokine levels, particularly interleukin-6 (IL-6), were detected in patients with cytokine storm (CS).
This study aimed to investigate levels, diagnostic usefulness, and optimal cutoff values of monocyte, eosinophil, neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) in CS of patients with COVID-19 and also to identify risk factors for mortality.
Seventy-six patients with COVID-19 who developed CS and randomly chosen 150 COVID-19 patients who had no CS during their stay in the hospital were included in the study.
Lymphocytes and eosinophil levels remained lower in the CS group. Patients with low lymphocyte levels had a higher risk for mortality (OR: 1.92). Neutrophil, D-dimer, ferritin, IL-6, NLR, and PLR were higher in the CS group. High levels of neutrophil, ferritin, D-dimer, and NLR and a history of coronary artery disease (CAD) and diabetes mellitus (DM) were identified as independent risk factors for mortality.
In the light of the obtained results, COVID-19 patients with a decrease in lymphocyte levels and an increase in NLR and D-dimer levels and a history of CAD and DM have a higher risk of cytokine storm and mortality.
在 COVID-19 大流行的早期阶段，细胞因子风暴（CS）患者的炎症细胞因子水平升高，特别是白细胞介素 6（IL-6）。
本研究旨在探讨 COVID-19 患者 CS 中单核细胞、嗜酸性粒细胞、中性粒细胞-淋巴细胞比值（NLR）和血小板-淋巴细胞比值（PLR）的水平、诊断有用性和最佳截断值，并确定死亡率的危险因素。
纳入了 76 例 COVID-19 患者发生 CS 以及随机选择的 150 例 COVID-19 患者在住院期间未发生 CS 的患者。
CS 组的淋巴细胞和嗜酸性粒细胞水平仍然较低。淋巴细胞水平较低的患者死亡率较高（OR：1.92）。CS 组的中性粒细胞、D-二聚体、铁蛋白、IL-6、NLR 和 PLR 水平较高。高水平的中性粒细胞、铁蛋白、D-二聚体和 NLR 以及冠状动脉疾病（CAD）和糖尿病（DM）病史被确定为死亡率的独立危险因素。
根据研究结果，淋巴细胞水平降低、NLR 和 D-二聚体水平升高以及 CAD 和 DM 病史的 COVID-19 患者发生细胞因子风暴和死亡率的风险较高。
