Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida 201310, India.
Shri Ram Murti Smarak College of Engineering and Technology (Pharmacy), Abheypur Keshonpur, India.
Anticancer Agents Med Chem. 2023;23(6):614-623. doi: 10.2174/1871520622666220810153735.
Cancer is a type of human cell degenerative disease that has afflicted a large number of people for years. Cancer is caused due to the abnormal proliferation of cells in any part of the body. Most of the prescribed anticancer drugs are synthetic in nature and have been reported with enormous adverse effects. The researchers are very much enthusiastic about the use of natural compounds and their derivatives, which have been reported with less toxicity. Natural compounds have emerged as promising synergistic compounds with potential anticancer effects. In vitro anticancer activity of natural compounds with special reference to camphor and menthol has been investigated against different cancer cell lines. It has been found that camphor and menthol derivatives have potential cytotoxic activity. The present literature review outlines the various methods for the synthesis of camphor and menthol derivatives, which have potential cytotoxic activity. It highlights various cancer cell lines, which are the target of these camphor and menthol derivatives as ligands, along with structure-activity studies.
癌症是一种人类细胞退行性疾病，多年来困扰着大量人群。癌症是由于身体任何部位的细胞异常增殖引起的。大多数规定的抗癌药物在性质上是合成的，并已被报道具有巨大的不良反应。研究人员非常热衷于使用天然化合物及其衍生物，这些化合物的毒性较小。天然化合物已成为具有潜在抗癌作用的有前途的协同化合物。已经研究了天然化合物的体外抗癌活性，特别是樟脑和薄荷醇，以对抗不同的癌细胞系。已经发现樟脑和薄荷醇衍生物具有潜在的细胞毒性活性。本文献综述概述了具有潜在细胞毒性活性的樟脑和薄荷醇衍生物的各种合成方法。它强调了作为配体的这些樟脑和薄荷醇衍生物的各种癌细胞系，以及结构活性研究。
