Clinical Nursing Department, Nursing College, Hubei University of Science and Technology, Xianning 437100, PR China.
Department of Neurosurgery, Xianning Central Hospital, Xianning 437100, PR China.
Chem Res Toxicol. 2022 Sep 19;35(9):1512-1518. doi: 10.1021/acs.chemrestox.2c00126. Epub 2022 Aug 11.
Brominated flame retardants (BFRs) are ubiquitous industrial chemicals. In China, BFRs that are applied in large quantities include decabromodiphenyl ether (BDE-209), tetrabromobisphenol A (TBBPA), and hexabromocyclododecane (HBCD). Although findings are not always unequivocal, mounting evidence suggests that the BFRs have potential neurotoxicity. The present study aimed to assess and compare the neurotoxic effects of these three BFRs' exposure. Male mice were orally exposed to BDE-209, TBBPA, or HBCD at 50 and 100 mg/kg bw/day for 28 days. The cognitive behavior, oxidative stress (ROS, MDA, and GSH), apoptosis-related genes (, , and ), memory-related proteins (BDNF and PSD-95), and neurotransmitters (AChE and ChAT) were detected comparatively. Results showed that high doses of BDE-209, TBBPA, and HBCD exposure impaired spatial memory of mice, elevated ROS and MDA and reduced GSH levels of hippocampus, upregulated and expressions, decreased BDNF and PSD-95 levels, and disordered AChE and ChAT levels. Notably, BDE-209 caused greater adverse effects > HBCD > TBBPA. This study confirms and extends that these three BFRs had similar neurotoxic effects at current concentrations, although they may be more or less toxic.
溴系阻燃剂（BFRs）是普遍存在的工业化学品。在中国，大量应用的 BFRs 包括十溴二苯醚（BDE-209）、四溴双酚 A（TBBPA）和六溴环十二烷（HBCD）。尽管研究结果并不总是一致，但越来越多的证据表明 BFRs 具有潜在的神经毒性。本研究旨在评估和比较这三种 BFRs 暴露的神经毒性作用。雄性小鼠经口暴露于 50 和 100mg/kg bw/day 的 BDE-209、TBBPA 或 HBCD 28 天。比较检测了认知行为、氧化应激（ROS、MDA 和 GSH）、凋亡相关基因（、和）、记忆相关蛋白（BDNF 和 PSD-95）和神经递质（AChE 和 ChAT）。结果表明，高剂量的 BDE-209、TBBPA 和 HBCD 暴露损害了小鼠的空间记忆，增加了海马体的 ROS 和 MDA 水平，降低了 GSH 水平，上调了和的表达，降低了 BDNF 和 PSD-95 水平，扰乱了 AChE 和 ChAT 水平。值得注意的是，BDE-209 引起的不良影响大于 HBCD 大于 TBBPA。本研究证实并扩展了这三种 BFRs 在目前浓度下具有相似的神经毒性作用，尽管它们的毒性可能或多或少。
