世界卫生组织 CNS5 2021 年胶质瘤分类：病理学家实用解读及诊断路标，以及恰当的病理临床与神经肿瘤学合作。

WHO CNS5 2021 classification of gliomas: a practical review and road signs for diagnosing pathologists and proper patho-clinical and neuro-oncological cooperation.

机构信息

Department of Pathomorphology and Forensic Medicine, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland.

Department of Pathology, The Children's Memorial Health Institute, Warsaw, Poland.

出版信息

Folia Neuropathol. 2022;60(2):137-152. doi: 10.5114/fn.2022.118183.

DOI:10.5114/fn.2022.118183

PMID:35950467

Abstract

The 5th edition of World Health Organization (WHO) Central Nervous System (CNS) tumours classification has transformed the pathological diagnosis of gliomas from purely histological to the multilayered integrated one with molecular biomarkers necessary for proper classification, risk stratification, and prognostic-predictive clinical purposes. Because of deep and important changes in taxonomy and diagnostic approach to gliomas, this manuscript is a review of WHO CNS classification 5th edition with general testing guidance for pathologists and clinicians working in neuro-oncology.

摘要

世界卫生组织（WHO）第五版中枢神经系统（CNS）肿瘤分类将胶质瘤的病理诊断从单纯的组织学转变为多层次的综合诊断，需要分子生物标志物来进行正确的分类、风险分层和预后预测的临床目的。由于胶质瘤的分类和诊断方法发生了深刻而重要的变化，因此本文档是对 WHO CNS 分类第五版的综述，为神经肿瘤学领域的病理学家和临床医生提供了一般检测指导。