Faruqui F I, Otten M D, Polimeni P I
Circulation. 1987 Mar;75(3):627-35. doi: 10.1161/01.cir.75.3.627.
The inhibitory effect of Separan AP-30, an anionic polyacrylamide, on atherosclerotic plaque formation in aortas of rabbits on a high (2%) cholesterol diet was tested over a period extending from 37 to 170 days. Atherogenesis was quantified morphometrically by application of a computer-assisted image analysis of histologic cross sections of the aorta. The area of vessel wall-atheroma interface, fraction of lumen occluded, and other indexes of atherogenesis were measured in each of 26 segments of aorta excised from the animals, half of which were administered injections (intravenous) of Separan three times a week. Regression analysis of the morphometric data indicates that the polyelectrolyte exerts a powerful antiatherogenic effect in all regions of the aorta, inhibiting the formation of plaque mass to less than half in the aortic arch and about one-fifth in the descending aorta as compared with the aortic plaque masses in untreated rabbits. Results are compatible with the suggestion that a novel hemodynamic principle in vivo, polymer drag reduction, might be effectively applied against atherosclerosis.
在为期37至170天的时间里，对阴离子聚丙烯酰胺Separan AP - 30抑制高胆固醇（2%）饮食的家兔主动脉粥样硬化斑块形成的作用进行了测试。通过对主动脉组织学横截面进行计算机辅助图像分析，对动脉粥样硬化形成进行形态计量学定量分析。从动物身上切除26段主动脉，测量每段血管壁 - 动脉粥样瘤界面面积、管腔闭塞分数及其他动脉粥样硬化形成指标，其中一半每周静脉注射三次Separan。形态计量数据的回归分析表明，该聚电解质在主动脉所有区域均发挥强大的抗动脉粥样硬化作用，与未治疗家兔的主动脉斑块质量相比，在主动脉弓中斑块质量抑制至不到一半，在降主动脉中约为五分之一。结果与以下观点相符，即体内一种新的血液动力学原理——聚合物减阻，可能有效地用于对抗动脉粥样硬化。
