Department of Chemistry and Nano Science, Ewha Womans University, Seoul, 03760, Republic of Korea.
Severance Biomedical Science Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Biosens Bioelectron. 2022 Nov 15;216:114612. doi: 10.1016/j.bios.2022.114612. Epub 2022 Aug 2.
Theranostic, which integrates the diagnosis and tumor treatment in tandem, is an emerging strategy in cancer treatment. Here, we report a novel and unique theranostic nanoparticle, HBCP NP, based on hexa-BODIPY cyclophosphazene (HBCP). Due to the unique bulky molecular structure of HBCP, this nanoparticle can simultaneously perform near-infrared (NIR) fluorescence imaging and photoacoustic imaging (PAI). Interestingly, since reactive oxygen species (ROS) generation of HBCP NPs is completely inhibited, 'safe' fluorescence imaging is possible without the risk of cell damage even under laser irradiation. Finally, NIR fluorescence imaging and PAI in 4T1 tumor-bearing mice demonstrated selective accumulation of HBCP NPs at tumor sites. In addition, HBCP NPs exhibited excellent photothermal effects under high-power laser irradiation, achieving effective tumor growth inhibition.
治疗诊断一体化，即在同一体系中同时实现诊断和肿瘤治疗，是癌症治疗的新兴策略。在此，我们报告了一种新型独特的治疗诊断一体化纳米粒子 HBCP NP，它基于六方 BODIPY 环磷腈（HBCP）。由于 HBCP 独特的庞大分子结构，该纳米粒子可以同时进行近红外（NIR）荧光成像和光声成像（PAI）。有趣的是，由于 HBCP NPs 中活性氧（ROS）的生成完全受到抑制，即使在激光照射下，也没有细胞损伤的风险，因此可以进行“安全”的荧光成像。最后，在荷 4T1 肿瘤小鼠中进行的 NIR 荧光成像和 PAI 显示，HBCP NPs 选择性地聚集在肿瘤部位。此外，HBCP NPs 在高功率激光照射下表现出优异的光热效应，实现了有效的肿瘤生长抑制。
